Evidence map›Paper›PMID 41264413›Full record

ArticleChemistry & biodiversity2026

Isoquinoline Alkaloids From Fibraurea recisa With Anti-acetylcholinesterase Activity.

Kai Zhao, Qian-Yi Situ, Miao Wang, Hui-Hui Zhu, Hai-Yue Zhao, Jian-Hui He, Qing Tang, Yu-Bo Zhang, Ke-Han Pei, Hui Sun and 1 more

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kai ZhaoState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Qian-Yi SituState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Miao WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Hui-Hui ZhuState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Hai-Yue ZhaoState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Jian-Hui HeState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Qing TangState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Yu-Bo ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Ke-Han PeiZhuzhou Qianjin Pharmaceutical Co., Ltd., Zhuzhou, P. R. China.
Hui SunHunan Institute for Drug Control, Changsha, P. R. China.
Guo-Cai WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0003-1196-7850

Funding

Guangdong Basic and Applied Basic Research Foundation 2020A1515110076National Natural Science Foundation of China 82173695National Natural Science Foundation of China 82273803National Natural Science Foundation of China 82373747
6 · The paper itself

Abstract

Two new 8-oxoprotoberberine alkaloids (1 and 2), one new isoquinoline alkaloid (8), and a pair of enantiomeric isoindolebenzazepine alkaloids (10a and 10b) were isolated from the vine stems of Fibraurea recisa Pierre. Their structures and absolute configurations were elucidated by spectroscopic methods (mass spectrometry, ultraviolet, infrared, one- and two-dimensional nuclear magnetic resonance), quantum chemical electronic circular dichroism calculations, and single-crystal X-ray crystallography. All isolated compounds were evaluated for acetylcholinesterase inhibitory activity, with compound 4 exhibiting significant inhibition.

Indexed as

AcetylcholinesteraseAlkaloidsCholinesterase InhibitorsIsoquinolinesCrystallography, X-RayModels, MolecularMolecular ConformationMolecular StructurePlant StemsStructure-Activity RelationshipAcetylcholinesteraseAlkaloidsCholinesterase InhibitorsisoquinolineIsoquinolinesanti‐acetylcholinesterase activityFibraurea recisa Pierreisoquinoline alkaloids

Identifiers

PMID41264413
PMCPMC13419890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.