Evidence map›Paper›PMID 41264241›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics.

Mark Widmaier, Antonia Kaiser, Pontus Pandurevic, Song-I Lim, André Döring, Zhiwei Huang, Daniel Wenz, Ying Xiao, Yun Jiang, Yan Lin and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mark WidmaierCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.
Antonia KaiserCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.ORCID 0000-0001-7805-6766
Pontus PandurevicCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.ORCID 0009-0008-1835-8197
Song-I LimCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.
André DöringCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.ORCID 0000-0002-2096-5374
Zhiwei HuangCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.
Daniel WenzCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.ORCID 0000-0002-3216-7599
Ying XiaoCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.
Yun JiangDepartment of Radiology, University of Michigan, Ann Arbor 1015, MI.ORCID 0000-0002-0713-9641
Yan LinDepartment of Radiology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China.
Lijing XinCIBM Center for Biomedical Imaging, Lausanne 1015, Switzerland.ORCID 0000-0002-5450-6109

Funding

3D High Resolution Magnetic Resonance Fingerprinting for Prostate CancerR37CA263583 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yun Jiang · 2021 to 2026
$3.8M
Quantitative MRI to automatically delineate intraprostatic tumor for radiation therapyR01CA284172 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI GUO, JIA, JIANG, YUN · 2024 to 2025
$1.4M
NCI NIH HHS R01 CA284172NCI NIH HHS R37 CA263583NIH/NCI R37CA263583 and R01CA284172Swiss National Science Foundation 213769Swiss National Science Foundation 320030 189064
6 · The paper itself

Abstract

The creatine kinase (CK) is a key enzyme involved in brain bioenergetics, playing an important role in brain function and the pathogenesis of neurological and psychiatric diseases and cancers. However, imaging its activity noninvasively in the human brain remains a significant challenge. This study aims to advance

Indexed as

BrainBrain MappingCreatine KinaseMagnetic Resonance ImagingAdultFemaleHumansKineticsMaleCreatine Kinase31P MRSbioenergeticsbraincreatine kinaseMRI

Identifiers

PMID41264241
PMCPMC12664012

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.