Evidence map›Paper›PMID 41264223›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2026

Development of surface-functionalized power-free microchip for breast cancer cell-derived extracellular vesicle detection.

Ryo Ishihara, Ryo Matsui, Tadaaki Nakajima, Hinako Yokohari, Ren Ogata, Kotomi Katori, Kazuo Hosokawa, Mizuo Maeda, Akihiko Kikuchi

Abstract read
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In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryo Ishihara *Faculty of Medicine, Juntendo University, Chiba, 270-1695, Japan. r-ishihara@juntendo.ac.jp.ORCID http://orcid.org/0000-0003-4862-4843
Ryo Matsui *Department of Materials Science and Technology, Tokyo University of Science, Tokyo, 125-8585, Japan.
Tadaaki NakajimaDepartment of Science, Yokohama City University, Kanazawa, 236-0027, Japan.
Hinako YokohariFaculty of Health and Sports Science, Juntendo University, Chiba, 270-1695, Japan.
Ren OgataFaculty of International Liberal Arts, Juntendo University, Tokyo, 113-8421, Japan.
Kotomi KatoriFaculty of Health and Sports Science, Juntendo University, Chiba, 270-1695, Japan.
Kazuo HosokawaRIKEN Cluster for Pioneering Research, RIKEN, Saitama, 351-0198, Japan.
Mizuo MaedaRIKEN Cluster for Pioneering Research, RIKEN, Saitama, 351-0198, Japan.
Akihiko KikuchiDepartment of Materials Science and Technology, Tokyo University of Science, Tokyo, 125-8585, Japan.

Funding

Japan Society for the Promotion of Science 18K18404Japan Society for the Promotion of Science 20K12697Japan Society for the Promotion of Science 23K11905
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have emerged as promising biomarkers for liquid biopsies because of their responsiveness to various physiological conditions. However, their dynamic physical properties pose significant analytical challenges, which necessitates the development of novel detection methods. In this study, a portable surface-functionalized power-free microchip (SF-PF microchip) was developed that enables the detection of EVs without external pumps. In particular, the SF-PF microchip specifically detected EVs derived from metastatic breast cancer cells with a limit of detection of 5.0 × 10

Indexed as

Breast NeoplasmsExtracellular VesiclesLab-On-A-Chip DevicesCell Line, TumorFemaleHumansSurface PropertiesBreast cancerDetectionExtracellular vesiclesPoint-of-care testingSurface-functionalized power-free microchip

Identifiers

PMID41264223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.