Evidence map›Paper›PMID 41264209›Full record

GuidelineHepatology international2025

Autoimmune hepatitis in children: Guidelines of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).

Rajeev Khanna, Bikrant Bihari Lal, Vikrant Sood, Seema Alam, Aabha Nagral, Aathira Ravindranath, Aditi Kumar, Aniket Deshmukh, Anoop Saraya, Anshu Srivastava and 47 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Hepatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Rajeev KhannaDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India, 110070.
Bikrant Bihari LalDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India, 110070.
Vikrant SoodDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India, 110070.
Seema AlamDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India, 110070. seema_alam@hotmail.com.ORCID http://orcid.org/0000-0003-0888-8625
Aabha NagralDepartment of Gastroenterology, Jaslok Hospital and Research Center, Mumbai, India.
Aathira RavindranathDepartment of Pediatric Gastroenterology, Apollo BGS Hospital, Mysuru, Karnataka, India.
Aditi KumarDepartment of Pediatrics, All India Institute of Medical Sciences, Bhubaneshwar, India.
Aniket DeshmukhDepartment of Pediatric Hepatology, Nanavati Max Superspeciality Hospital, Vile Parle, Mumbai, India.
Anoop SarayaDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Anshu SrivastavaDepartment of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Anupam SibalDepartment of Pediatric Gastroenterology and Liver Transplantation, Indraprastha Apollo Hospitals, New Delhi, India.
Archana RastogiDepartment of Pathology, Institute of Liver and Biliary Sciences, New Delhi, India.
Arjun MariaDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplant, Amrita Institute of Medical Sciences and Hospital, Faridabad, India.
Arul Premanand LionelDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Christian Medical College, Vellore, India.
Ashok ChoudhuryDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
A AshrithaDivision of Pediatric Hepatology and Liver Transplantation, Integrated Liver Care, Aster Hospitals, Bengaluru, India.
Bhaswati C AcharyyaDepartment of Pediatric Gastroenterology, Institute of Child Health, Kolkata, India.
Cara L MackDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, USA.
Durga PrasadDepartment of Pediatric Gastroenterology, Medanta Super Speciality Hospital, Lucknow, India.
Geetha S MammayilDepartment of Pediatric Gastroenterology, Aster Medcity, Kochi, India.
Ishaq MalikDepartment of Pediatrics, Government Medical College, Srinagar, India.
Jagadeesh MenonDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplant, Dr Rela Institute and Medical Center, Chennai, India.
Jayendra SeetharamanDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Christian Medical College, Vellore, India.
John MatthaiDepartment of Pediatric Gastroenterology, Masonic Children Hospital, Coimbatore, India.
Kalpana PandaDepartment of Pediatrics, Institute of Medical Sciences and SUM Hospital, Bhubaneshwar, India.
Karunesh KumarDepartment of Pediatric Gastroenterology and Liver Transplantation, Indraprastha Apollo Hospitals, New Delhi, India.
Lalit BharadiaPediatric Gastroenterology, Neoclinic Children Hospital, Jaipur, India.
Marion AwDivision of Pediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation, Department of Pediatrics, National University Health System, Singapore, Singapore.
Malathi SathiyasekaranDepartment of Pediatric Gastroenterology, Rainbow Children's Hospital, Chennai, India.
Marianne SamynDepartment of Pediatric Hepatology, King's College Hospital, London, UK.
Maya PeethambaranDepartment of Pediatric Gastroenterology and Hepatology, VPS Lakeshore Hospital, Kochi, Kerala, India.
Moinak Sen SarmaDepartment of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Nagendra KumarDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Rainbow Hospitals and Indira Gandhi Institute of Child Health, Bengaluru, India.
Nanda KerkarDivision of Pediatric Gastroenterology and Nutrition, Section of Pediatric Hepatology and Liver Transplant, Massachusetts General Brigham for Children, Boston, USA.
Nirmala DheivamaniDepartment of Pediatric Gastroenterology, Institute of Child Health and Hospital for Children, Chennai, India.
Parijat Ram TripathiDepartment of Pediatric Gastroenterology and Hepatology, Ankura Hospital for Women and Children, Hyderabad, India.
Piyush UpadhyayDepartment of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Prabhsaran KaurDepartment of Gastroenterology, Seth G S Medical College and KEM Hospital, Mumbai, India.
Prasanth K SobhanDivision of Pediatric Gastroenterology, Department of Pediatrics, SAT Hospital, Government Medical College, Thiruvananthapuram, India.
Rakhi MaiwallDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
R Bhanu Vikraman PillaiDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Amrita Hospital, Kochi, India.
Sadhna LalDepartment of Pediatric Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sakshi KarkraDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplant, Artemis Hospital, Gurugram, India.
Shivani DeswalDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplant, Narayana Health, DLF Phase 3, Gurugram, India.
Snehavardhan PandeyDepartment of Pediatric Hepatology and Liver Transplantation, Sahyadri Superspeciality Hospital Pvt Ltd, Pune, India.
Somashekara Hosaagrahara RamakrishnaDepartment of Pediatric Hepatology and Liver Transplantation, Rainbow Children's Hospital, Chennai, India.
Srikanth P KadyadaPediatric Gastroenterology, Hepatology and Nutrition, Manipal Hospitals, Bengaluru, India.
Srinivas SankaranarayananDepartment of Pediatric Gastroenterology and Hepatology, Kanchi Kamakoti Childs Trust Hospital, Chennai, India.
Surender Kumar YachhaDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplantation, Sakra World Hospital, Bangalore, India.
Sumathi BavanandamDepartment of Gastroenterology, Stanley Medical College, Chennai, India.
Sumit Kumar SinghDepartment of Pediatric Gastroenterology and Hepatology, Choithram Hospital and Research Centre, Indore, India.
Vaibhav ShahDepartment of Pediatric Hepatology and Gastroenterology, Gujarat Superspeciality Clinic, Ahmedabad, India.
Vibhor BorkarDepartment of Pediatric Hepatology, Gastroenterology and Liver Transplantation, Gleneagles Hospital, Mumbai, India.
Vikas JainDepartment of Pediatric Gastroenterology, Postgraduate Institute of Child Health, Noida, India.
Vipul GautamDepartment of Pediatric Gastroenterology, Hepatology and Liver Transplantation, Max Superspeciality Hospital, New Delhi, India.
Viswanathan M SivaramakrishnanDepartment of Pediatric Gastroenterology and Hepatology, Apollo Children's Hospital, Chennai, India.
Shiv Kumar SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune hepatitis (AIH) in children presents significant diagnostic and therapeutic challenges requiring a multidisciplinary and evidence-based approach. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN) convened a consensus meeting on February 23, 2025, bringing together national and international experts to address key clinical and research questions. The deliberations spanned epidemiology, clinical presentation, diagnosis including autoantibodies, immunoglobulin G (IgG), histology and diagnostic scores, therapeutic strategies, management of difficult-to-treat AIH, long-term monitoring, and special scenarios, such as seronegative AIH (SN-AIH), autoimmune sclerosing cholangitis/overlap syndromes and post-transplant complications like recurrence and de novo-AIH. Recommendations were formulated using standard GRADE system and finalized through structured consensus. These guidelines aim to standardize care, assist clinicians in decision-making, and improve outcomes in children with AIH across diverse healthcare settings.

Indexed as

Hepatitis, AutoimmuneAutoantibodiesChildGastroenterologyHumansIndiaPediatricsSocieties, MedicalAutoantibodiesAutoantibodiesAutoimmune acute liver failureChildrenChronic liver diseaseImmunoglobulinLiver transplantation

Identifiers

PMID41264209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.