ArticleActa parasitologica2025
Capsaicin, a Vanilloid Derivative, Modulates Arginine Kinase mRNA Expression in Trypanosoma evansi.
Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTrypanosoma evansi, the causative agent of Surra, is a significant emerging zoonotic kinetoplastid protozoan parasite with wide host range and limited chemotherapeutic options. Arginine kinase is mainly responsible for providing metabolic plasticity and maintaining cellular homeostasis of trypanosome under adverse conditions.
methodsThis study investigated the in vitro anti-trypanosomal activity of Vanilloid derivative, Capsaicin against T. evansi and its effect on mRNA expression of arginine kinase enzyme in T. evansi. Herein, we determined the anti-trypanosomal activity of Capsaicin against T. evansi and its safety towards mammalian cells by estimating the selectivity index. From the dataset generated during the experiments, the IC
resultsCytotoxicity assays showed that Capsaicin exhibited moderate cytotoxicity against equine PBMC and Vero cells line with CC
conclusionThe study suggests that Capsaicin may be a potential approach for treating T. evansi infections, warranting further in vivo investigations.
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