Evidence map›Paper›PMID 41264082›Full record

ArticleAmino acids2025

Novel octapeptide containing the RGD sequence as a potential anti-SARS-CoV-2 agent: design, synthesis, and theoretical studies.

Reiner Lemos, Orlando Ortiz, Luis Almagro, Kamil Makowski, Hortensia Rodríguez, Fernando Albericio, Margarita Suárez

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Reiner LemosLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, La Habana, 10400, Cuba. reinier.lemos@fq.uh.cu.
Orlando OrtizLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, La Habana, 10400, Cuba.
Luis AlmagroLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, La Habana, 10400, Cuba.
Kamil MakowskiDepartment of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia. (IQAC-CSIC), Barcelona, 08034, Spain.
Hortensia RodríguezSchool of Chemical Sciences and Engineering, Yachay Tech Medicinal Chemistry Research Group (MedChem-YT), Yachay Tech University, 100119, Urququi, Ecuador.
Fernando AlbericioPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, 4001, South Africa. albericio@ukzn.ac.za.
Margarita SuárezLaboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, La Habana, 10400, Cuba. msuarez@fq.uh.cu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The design of peptide-based inhibitors targeting cell receptors represents a promising strategy in the development of antiviral agents. In this study, a novel octapeptide containing the RGD sequence was rationally designed to explore its potential interaction with integrins. The peptide was functionalized with a malonic moiety to enhance its binding capabilities and potential bioactivity. Conformational and physicochemical properties were evaluated using DFT-PBEh-3c calculations. Molecular docking studies revealed favorable interactions with the integrin α

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentOligopeptidesSARS-CoV-2Drug DesignHumansMolecular Docking SimulationAntiviral Agentsarginyl-glycyl-aspartic acidOligopeptidesDFT calculationsIntegrin α5β1RGD motifSolid-phase peptide synthesis

Identifiers

PMID41264082
PMCPMC12657584

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.