Evidence map›Paper›PMID 41264056›Full record

ArticleMolecular biology reports2025

Toll-like receptor 3 (TLR 3) polymorphisms predisposition to schizophrenia and bipolar disorder.

Youssef Aflouk, Oumaima Inoubli, Nawres Maafi, Saloua Yacoub, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youssef AfloukLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia. afloukyoussef1@gmail.com.ORCID http://orcid.org/0000-0002-1155-4039
Oumaima InoubliLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia.
Nawres MaafiLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia.
Saloua YacoubRegional Center of Blood Transfusion, University Hospital Farhat Hached, Sousse, 4000, Tunisia.
Ferid ZaafraneDepartment of Psychiatry, University Hospital Fattouma Bourguiba Monastir, Monastir, 5000, Tunisia.
Lotfi GahaDepartment of Psychiatry, University Hospital Fattouma Bourguiba Monastir, Monastir, 5000, Tunisia.
Besma Bel Hadj JradLaboratory of Genetics, Biodiversity and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundToll-like receptor 3 (TLR 3) abnormal inflammatory response was described as one of the possible mechanisms implicated in the pathophysiology of schizophrenia (SCZ) and bipolar disorder (BD). However, the genetic predisposition of TLR 3 to these disorders' onset is still unclear. Therefore, the predisposition of TLR 3 functional variants L412F (rs3775291) and F459L (rs3775290) was examined in both disorders. METHODS AND

resultsIn a case-control study, 260 controls, 260 SCZ, and 130 BD patients were recruited and genotyped by PCR-RFLP. Genotypes, alleles, and haplotypes frequencies were compared between controls and patients based on clinical features. Statistical analyses were adjusted by gender and age and validated by Bonferroni correction. In the dominant model, our results showed significantly higher L412F AA + GA frequency in controls compared to BD patients (p

conclusionsThe present study suggests that L412F could be a protective genetic factor from BD onset. However, F459L could be a genetic risk factor for the paranoid subtype and a potential genetic predictor of SCZ negative symptoms treatment improvement.

Indexed as

Bipolar DisorderGenetic Predisposition to DiseaseSchizophreniaToll-Like Receptor 3AdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenotypeHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideTLR3 protein, humanToll-Like Receptor 3Antipsychotic treatmentBipolar disorderF412LL459FSchizophreniaTLR 3

Identifiers

PMID41264056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.