ArticleHead and neck pathology2025
YAP1::MAML2-Rearranged Poroid Squamous Cell Carcinoma Arising in a Non-sebaceous Lymphadenoma of the Parotid Gland.
Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Skin-analogue primary poroid neoplasms of the head and neck with YAP1/WWTR1::MAML2/NUTM1 fusions: clinicopathologic and genetic spectrum of a novel tumor family delineated in a series of 10 cases.Virchows Archiv : an international journal of pathology · 2026Article
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3 authors.
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Abstract
Salivary gland lymphadenoma is an uncommon neoplasm and malignant transformation is even rarer. Reported tumor types include basal cell adenocarcinoma, sebaceous carcinoma, EBV-associated lymphoepithelial carcinoma, and undifferentiated carcinoma; a squamous phenotype has not been reported. Here we describe the case of a 62-year-old female who underwent total parotidectomy for a painful parotid gland mass of uncertain duration. On microscopic examination, a high grade lymphoepithelial carcinoma with squamous and poroid features arising in a non-sebaceous lymphadenoma was recognized. Both benign and malignant components expressed CK5/6 and ΔNp63 (p40), however SOX2 was overexpressed in the malignant component. S100, SOX10, CD117, PLAG1 and HMGA2 immunostains were negative. In-situ hybridization for high-risk HPV RNA and EBER were also negative. Fluorescence in situ hybridization revealed MAML2 rearrangement with RNASeq confirming a YAP1::MAML2 fusion product. This case highlights a novel salivary gland malignancy type arising from lymphadenoma, for which molecular testing was critical in establishing primary origin, and thus excluding the more common metastatic squamous cell carcinoma.
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