ArticleExperimental brain research2025
Reduced volume in the amygdala of trigeminal neuralgia patients: a neuroimaging study with clinical correlates.
Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A modified FLIT-B model of trigeminal neuralgia reveals anterior cingulate cortex involvement in anxiety-like behavior in mice.The journal of headache and pain · 2026Article
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7 authors.
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Abstract
Trigeminal neuralgia (TN) is characterized by intense and recurrent episodes of pain in the orofacial region, mainly affecting the second (V2) and third (V3) divisions of the trigeminal nerve. Recent studies suggest that TN may be associated with structural alterations in the limbic system, particularly the amygdala, a core region for the emotion-related network, involved in emotional aspects of pain and pain modulation. This study evaluated the volumetry of the amygdala and its nine nuclei in patients with TN compared to healthy controls. Structural Magnetic Resonance Imaging (MRI) data were analyzed from 111 TN patients and 48 healthy volunteers. MRI scans were acquired using a 3 T MRI scanner with high-resolution 3D T1w sequences (2022-2024) at the Federal Neurosurgical Center in Novosibirsk, Russia, and assessed via the OpenNeuro database. Amygdala volumetry was performed using FreeSurfer software. Morphometric analysis revealed significantly lower volumes of both the left (p = 0.02, η
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