Evidence map›Paper›PMID 41263994›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Quercetin as a promising HIS-C inhibitor and novel therapeutic against antibacterial drug-resistant Acinetobacter baumannii: in vitro and in silico insights.

Mohammed Salleh M Ardawi, Samar A Badreddine, Muhammad Yasir, Safaa A Turkistani, Ahmed Afandi, Abdulaziz A Kimawi, Samah O Noor, Adhari Alselmi, Salma Mohammed Alsayed, Mada S Alharthi and 3 more

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Mohammed Salleh M ArdawiDepartment of Pathological Sciences, Fakeeh College for Medical Sciences, and Fakeeh Care Group, Jeddah, Saudi Arabia.
Samar A BadreddineInfection Control Department, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
Muhammad YasirDepartment of Pathological Sciences, Fakeeh College for Medical Sciences, and Fakeeh Care Group, Jeddah, Saudi Arabia.
Safaa A TurkistaniMedical Laboratory Sciences, Fakeeh College for Medical Sciences, and Fakeeh Care Group, Jeddah, Saudi Arabia.
Ahmed AfandiDepartment of Surgery, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
Abdulaziz A KimawiDepartment of Surgery, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
Samah O NoorDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Adhari AlselmiClinical Sciences Department-MBBS Program, Fakeeh College for Medical Sciences, 21461, Jeddah, Saudi Arabia.
Salma Mohammed AlsayedSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Mada S AlharthiSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Vivek Dhar DwivediCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospitals, Saveetha University, Chennai, India.
Pradeep SharmaDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, India. pradeepbdk@gmail.com.
Esam I AzharSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589, Jeddah, Saudi Arabia. eazhar@kau.edu.sa.

Funding

Dr. Mazen Fakeeh Academic Chair of Diabetes Mellitus at Dr. Soliman Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia MFSC-DM/04/24
6 · The paper itself

Abstract

Acinetobacter baumannii (A. baumannii), a common hospital-associated pathogen, is known for its rapid ability to develop antibacterial drug resistance. The HIS-C enzyme in this pathogen is essential for histidine biosynthesis, making this a prominent drug target for antimicrobial therapy. This experimental investigation analyzes the inhibitory function of quercetin, a well-known antibacterial flavonoid, on HIS-C enzyme through the in vitro and in silico approaches. The binding affinity between quercetin and HIS-C was further examined through in vitro assays. Further, the surface plasmon resonance (SPR) experiments confirmed the strong binding affinity, with a dissociation constant (KD) of 3.3 × 10

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsQuercetinComputer SimulationDrug Resistance, BacterialMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsBacterial ProteinsQuercetinAcinetobacter baumanniiHIS-C enzymeQuercetin

Identifiers

PMID41263994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.