ArticlePediatric cardiology2026
Genetic Evaluation Practices for Neonates with Congenital Heart Disease in Pediatric Cardiac Intensive Care Units: Findings from a Multi-institutional Survey.
Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Diagnostic yield of exome and genome sequencing for critically ill pediatric cardiac patients.Translational pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic testing plays an expanding role in pediatric cardiology, particularly in congenital heart disease (CHD). Despite advancements in genomic medicine, no universal guidelines exist for genetic evaluation in CHD, resulting in varied practices, especially within Cardiac Intensive Care Units (CICUs). This study examines genetic evaluation practices for neonates with CHD cared for in pediatric CICUs across the United States. A two-tier survey of CICU medical directors and genetic specialists was distributed via RedCap to 118 centers contributing to the Society of Thoracic Surgeons Congenital Heart Surgery Database. Surveys assessed CICU demographics, genetic evaluation practices, and institutional protocols. Descriptive statistics were analyzed using R. Fifty unique institutions (42%) completed the first-tier survey; 46/50 completed the second-tier. Most (78%) respondents reported dedicated CICUs, but only 32% had formal genetic testing protocols. Tier 1 showed genetic testing was reported in 58% of neonatal CHD cases, the remainder evaluated on a case-by-case basis. Substantial variability existed in both cardiac substrates prompting genetic evaluation and first-line test selection. Only 28% reported consultation with genetic providers for neonatal CHD cases. Tier 2 showed genetic consultation increased to 54% for patients with syndromic CHD, and genetic testing was obtained in 46% of isolated and 61% of syndromic CHD. Access remained limited as only 42% had cardiac-specific genetic providers. Fewer than 12% of institutions used exome or genome as first-line testing. Genetic evaluation in CICUs is highly variable, with underutilization of genetic providers and limited access to advanced testing. Standardized guidelines and consensus statements are needed to improve access, streamline care, optimize outcomes, and enable genome-informed management in CHD.
Indexed as
Identifiers
41263974What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.