Evidence map›Paper›PMID 41263964›Full record

ArticleEuropean radiology2026

Single-visit cardiac functional assessment by cine CT added to CCTA: segment-level validation of low-dose recirculation timing protocol.

Naoki Nagasawa, Satoshi Nakamura, Naoki Hashimoto, Akio Yamazaki, Yoshitaka Goto, Suguru Araki, Shintaro Yamaguchi, Hajime Sakuma, Kakuya Kitagawa

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naoki NagasawaDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Satoshi NakamuraDepartment of Advanced Diagnostic Imaging, Mie University Graduate School of Medicine, Tsu, Japan. s-nakamura@med.mie-u.ac.jp.ORCID http://orcid.org/0000-0002-9634-9332
Naoki HashimotoDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Akio YamazakiDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Yoshitaka GotoDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Suguru ArakiDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Shintaro YamaguchiDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Hajime SakumaDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Kakuya KitagawaDepartment of Advanced Diagnostic Imaging, Mie University Graduate School of Medicine, Tsu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCoronary CT angiography (CCTA) using retrospective helical scanning allows for cardiac function but requires high radiation exposure. This study aimed to investigate the optimal timing and feasibility of low-dose cine CT during the recirculation phase of the contrast agent. MATERIALS AND

methodsWe conducted a retrospective analysis of MR perfusion examinations in 38 patients to determine the recirculation timing of the contrast agent, and, based on the findings of the MR perfusion study, a feasibility study of a low-dose cine CT during the recirculation phase was performed for 51 patients with suspected or known coronary artery disease.

resultsThe MR perfusion study identified approximately 20 s after the contrast peak in the left ventricle (19.5 ± 4.3 HU) as the optimal recirculation time of contrast agent, with no significant correlation between left ventricular function and the timing. In cine CT images, CT values within the left (290.2 ± 42.1 HU) and right (264.1 ± 36.9 HU) ventricles were almost identical during the recirculation phase, with better contrast (p < 0.001) in the right atrium and ventricle compared to first-pass CCTA images. Cine CT showed high inter-rater reliability for left and right ventricular function assessment and better diagnostic performance than echocardiography for myocardial infarction assessment. The combined dose for CCTA (2.0 mSv) and cine CT (0.9 mSv) was 2.9 mSv.

conclusionA brief cine CT acquisition added to CCTA, timed to contrast recirculation, provides global and regional left ventricular function at a small incremental radiation dose (approximately 1 mSv). This single-visit protocol is a valuable alternative when echocardiography or MRI access is restricted or multiple examinations are not feasible. KEY POINTS: Question This study aimed to investigate the optimal timing and feasibility of low-dose cine CT during the recirculation phase of the contrast agent. Findings A 20-s recirculation time enabled low-dose cine CT (0.9 mSv) that allowed for effective cardiac function assessment. Clinical relevance When coronary CT is already indicated, a short cine acquisition can provide complementary functional information and may reduce additional testing in selected patients.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseAgedContrast MediaFeasibility StudiesFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedRadiation DosageReproducibility of ResultsRetrospective StudiesContrast MediaCardiac functionCCTACine CTRadiation dose reductionRecirculation phase

Identifiers

PMID41263964

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.