Evidence map›Paper›PMID 41263844›Full record

ArticleBMJ open2025

Efficacy and safety of hyaluronic acid-enriched transfer medium in women undergoing single blastocyst transfer: a study protocol for a multicentre randomised controlled trial.

He Cai, Dingfei Xu, Zhiqiang Wang, Bo Huang, Xia Xue, Haiyan Bai, Yuanyuan Man, Dan Lei, Qiongfang Wu, Yali Ni and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06492785 (Use of Hyaluronic Acid-enriched Transfer Medium in Women Undergoing Single Blastocyst Transfer), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06492785 narecruitingnot on this map

Use of Hyaluronic Acid-enriched Transfer Medium in Women Undergoing Single Blastocyst Transfer : a Multicenter, Randomized Controlled Trial

TypeinterventionalSponsorNorthwest Women's and Children's Hospital, Xi'an, ShaanxiRan2024 to 2025Enrolled858ConditionsInfertilityArmsHigh Hyaluronic Acid concentrations (0.5 mg/ml), Low Hyaluronic Acid concentrations (0.125 mg/ml)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

He CaiNorthwest Women and Children's Hospital, Xi'an, Shaanxi, China.ORCID http://orcid.org/0000-0003-0890-8913
Dingfei XuNanchang Medical College, Nanchang, Jiangxi, China.
Zhiqiang WangGansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China.
Bo HuangHuazhong University of Science and Technology, Wuhan, Hubei, China.
Xia XueNorthwest Women and Children's Hospital, Xi'an, Shaanxi, China.
Haiyan BaiNorthwest Women and Children's Hospital, Xi'an, Shaanxi, China.
Yuanyuan ManNorthwest Women and Children's Hospital, Xi'an, Shaanxi, China.
Dan LeiNorthwest Women and Children's Hospital, Xi'an, Shaanxi, China.
Qiongfang WuNanchang Medical College, Nanchang, Jiangxi, China.
Yali NiGansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China.
Jin LeiHuazhong University of Science and Technology, Wuhan, Hubei, China.ORCID http://orcid.org/0000-0003-0367-7765
Juanzi ShiNorthwest Women and Children's Hospital, Xi'an, Shaanxi, China shijuanziart@126.com.ORCID http://orcid.org/0009-0009-7643-4124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEmbryoGlue, a commercially available hyaluronic acid (HA)-enhanced culture medium, is commonly recommended as an adjunct to support embryo implantation. Given the current lack of conclusive evidence regarding its efficacy and safety, this study aims to evaluate the effectiveness and safety of HA-enriched medium in women undergoing in vitro fertilisation (IVF) treatment. METHODS AND ANALYSIS: This multicentre, patient-blinded, randomised controlled trial involves couples planning a single fresh or frozen blastocyst-stage embryo transfer. On the morning of embryo transfer, individual blastocysts are randomly allocated to either a high-concentration HA medium (EmbryoGlue, 0.5 mg/mL) or a conventional low-concentration HA medium (G-2 PLUS, 0.125 mg/mL). The primary outcome is live birth rate per embryo transfer, with secondary outcomes including biochemical pregnancy rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate, ongoing pregnancy rate, multiple pregnancy rate, as well as obstetric and perinatal outcomes and related complications. The trial plans to enrol 858 female patients from four IVF centres in China, with 429 patients in each group. ETHICS AND DISSEMINATION: The study has been approved by the Ethics Committee of Northwest Women's and Children's Hospital (approval no.: 2024-127), and all participating centres have obtained approvals from their respective institutional review boards or ethics committees. Results will be disseminated through publication in a peer-reviewed open-access journal and oral presentations at relevant domestic and international academic conferences. TRIAL REGISTRATION NUMBER: NCT06492785.

Indexed as

Culture MediaEmbryo TransferFertilization in VitroHyaluronic AcidSingle Embryo TransferAdultChinaFemaleHumansLive BirthMulticenter Studies as TopicPregnancyPregnancy RateRandomized Controlled Trials as TopicCulture MediaHyaluronic AcidRandomized Controlled TrialReproductive medicineResearch Design

Identifiers

PMID41263844
PMCPMC12636901

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.