Evidence map›Paper›PMID 41263832›Full record

ArticleBMJ open2025

State of Ohio Adversity and Resilience (SOAR) study protocol: a comprehensive, multimodal, family-based, longitudinal observational investigation of risk and resilience in mental health and substance use disorders.

Anthony P King, Scott Langenecker, Stephanie M Gorka, Jessica Turner, Lei Wang, Heather Wastler, Marybel Gonzalez, Lisa M Christian, Canada Keck, Randall Olsen and 53 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

63 authors.

Anthony P KingPsychiatry and Behavioral Health, Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio, USA anthony.king@osumc.edu.ORCID http://orcid.org/0000-0002-0764-9625
Scott LangeneckerPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Stephanie M GorkaPsychiatry and Behavioral Health, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio, USA.
Jessica TurnerPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Lei WangPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Heather WastlerPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Marybel GonzalezPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Lisa M ChristianPsychiatry and Behavioral Health, Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio, USA.
Canada KeckCHRR, The Ohio State University, Columbus, Ohio, USA.
Randall OlsenCHRR, The Ohio State University, Columbus, Ohio, USA.
Hyoshin KimDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA.
Brett KlamerNationwide Children's Hospital, Columbus, Ohio, USA.
Soledad FernandezDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA.
Caleb AdlerPsychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Elissar AndariPsychiatry, University of Toledo Community & Technical College, Toledo, Ohio, USA.
Stacey L BarrengerPsychiatry, Northeast Ohio Medical University College of Medicine, Rootstown, Ohio, USA.
Natalie BonfinePsychiatry, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Melanie BozzayPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Susan L BrownBowling Green State University, Bowling Green, Ohio, USA.
Christopher BrowningSociology, The Ohio State University, Columbus, Ohio, USA.
Katie BurkhousePsychology, Penn State University, University Park, Pennsylvania, USA.
Kathleen CarterCentral State University, Wilberforce, Ohio, USA.
Kim CecilUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID http://orcid.org/0000-0001-8233-5485
Karin G CoifmanPsychological Sciences, Kent State University, Kent, Ohio, USA.ORCID http://orcid.org/0000-0002-2372-0081
Emil CoccaroPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Timothy N CrawfordDepartments of Family Medicine and Population and Public Health Sciences, Wright State University, Kettering, Ohio, USA.ORCID http://orcid.org/0000-0001-8005-4495
Cory CroninOhio University, Athens, Ohio, USA.
Melissa DelbelloPsychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Anne-Marie DucheminPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Steven W EvansOhio University, Athens, Ohio, USA.
Chris FlaskPsychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
K Jean ForneyPsychology, Ohio University, Athens, Ohio, USA.
Larrilyn GrantPsychiatry, Wright State University, Dayton, Ohio, USA.
John GunstadDepartment of Psychology, Kent State University, Kent, Ohio, USA.
Paul J HershbergerPsychology, Wright State University, Dayton, Ohio, USA.
Kristen R HoskinsonPsychiatry, Nationwide Children's Hospital, Columbus, Ohio, USA.
Christina KleinPsychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Sara KoenigThe Ohio State University, Columbus, Ohio, USA.
Molly McVoyPsychiatry, University Hospitals of Cleveland, Cleveland, Ohio, USA.
Paula K MillerPsychology, Ohio University, Athens, Ohio, USA.
Jose MorenoPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Eric E NelsonPsychiatry, Nationwide Children's Hospital, Columbus, Ohio, USA.
Randolph NesseArizona State University, Tempe, Arizona, USA.
Christopher NguyenPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Kei NomaguchiDepartment of Sociology, Bowling Green State University, Bowling Green, Ohio, USA.
Alissa PaolellaCentral State University, Wilberforce, Ohio, USA.
Edison PerdomoCentral State University, Wilberforce, Ohio, USA.
Colin OddenResearch Information Technology, The Ohio State University, Columbus, Ohio, USA.
Martha SajatovicPsychiatry, Case Western Reserve University Hospital, Cleveland, Ohio, USA.
Robert McCullumsmithPsychiatry, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.
Jonathan TrauthCentral State University, Wilberforce, Ohio, USA.
Ivy TsoPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Xin WangPsychiatry, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.
Jennifer T WeinandyPsychology, Ohio University, Athens, Ohio, USA.
Krista K Westrick-PayneDepartment of Sociology, Bowling Green State University, Bowling Green, Ohio, USA.
Greta WinbushCentral State University, Wilberforce, Ohio, USA.
Brian T WymbsPsychology, Ohio University, Athens, Ohio, USA.
Hong XiePsychiatry, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA.
Steve GavazziCHRR, The Ohio State University, Columbus, Ohio, USA.
Timothy R HuertaResearch Information Technology, The Ohio State University, Columbus, Ohio, USA.
Grace Maynard-WentzelPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
Nina KraguljacPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.
K Luan PhanPsychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.

Funding

Socio-cultural and community risk and resilience for alcohol related problems in youthK01AA030325 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Marybel Robledo Gonzalez · 2023 to 2026
$681k
NIAAA NIH HHS K01 AA030325
6 · The paper itself

Abstract

introductionDeaths related to drug overdose and suicide in the USA have increased 500% and 35%, respectively, over the last two decades. The human and economic costs to society associated with these 'deaths of despair' are immense. Great efforts and substantial investments have been made in treatment and prevention, yet these efforts have not abated these increasing trajectories of deaths over time. The COVID-19 pandemic has exacerbated and highlighted these problems. Notably, some geographical areas (eg, Appalachia, farmland) and some communities (eg, low-income persons, 'essential workers', minoritised populations) have been disproportionately affected. Risk factors have been identified for substance use and suicide deaths: forms of adversity, neglect, opportunity indexes and trauma. Yet, the biological, psychological and social mechanisms driving risk are not uniform. Notably, most people exposed to risk factors do not become symptomatic and could broadly be considered resilient. Achieving a better understanding of biological, psychological and social mechanisms underlying both pathology and resilience will be crucial for improving approaches for prevention and treatment and creating precision medicine approaches for more efficient and effective treatment. METHODS AND ANALYSIS: The State of Ohio Adversity and Resilience (SOAR) study is a prospective, longitudinal, multimodal, integrated familial study designed to identify biological, psychological and social risk and resilience factors and processes leading to mental health disorders, substance use disorders, substance overdose, suicide and associated psychological/medical comorbidities which reduce life expectancy and quality of life. It includes two nested longitudinal samples: (1) WD Survey: an address-based random population epidemiological sample of 15 000 individuals (unique households) representative of the state of Ohio assessed for psychosocial, psychiatric, behavioural health and substance use factors and (2) Brain Health Study: a family-based, multimodal, deep-phenotyping study conducted in 1200 families (up to 3600 persons aged 12-72 years) including MRI, electroencephalography, blood biomarkers and psychiatric diagnostic interviews, as well as neuropsychological, psychosocial functioning and family/community history, dynamics and support assessments. SOAR is designed to discover, develop and deploy advanced predictive analytics and interventions to transform mental health prevention, diagnosis, treatment and recovery. ETHICS AND DISSEMINATION: All participants will provide written informed consent (or parental permission and assent for minors). The study was approved by The Ohio State University Institutional Review Board (study numbers 2023H0316 (Brain Health) and 2023H0350 (Wellness Survey). The Brain Health study was also approved by institutional review boards at each partnering institution involved in conducting participant assessments. Findings will be disseminated to academic peers, clinicians and healthcare consumers, policymakers and the general public, using local and international academic channels (academic journals, evidence briefs and conferences) and outreach (workshops and seminars).

Indexed as

COVID-19Mental DisordersMental HealthResilience, PsychologicalSubstance-Related DisordersAdolescentAdultFemaleHumansLongitudinal StudiesMaleObservational Studies as TopicOhioRisk FactorsSARS-CoV-2SuicideEPIDEMIOLOGIC STUDIESMENTAL HEALTHNeurobiologyRisk FactorsSubstance misuseSuicide & self-harm

Identifiers

PMID41263832
PMCPMC12658514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.