ArticleJACC. Advances2025
Association Between Cancer Treatment History and Coronary Inflammation.
Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have established a strong link between a cancer history and an increased risk of cardiovascular events.
objectivesThis study aimed to determine whether a cancer history is independently associated with coronary inflammation, a key driver of atherosclerotic plaque development.
methodsThis study included 1141 patients who underwent coronary computed tomography angiography from 2017 to 2018. We divided the patients into 2 groups based on the cancer history: 953 noncancer patients and 188 cancer patients. Coronary inflammation was quantified using the perivascular fat attenuation index (FAI) in the right coronary artery, with high-FAI defined as above the 75th percentile. Multivariable Poisson regression with robust error variance was employed to evaluate the relationship between cancer history and high-FAI, adjusting for conventional cardiovascular risk factors.
resultsThe median age and FAI in the overall study population were 70 years and -75.8 HU, respectively. Multivariable analysis revealed a significantly increased prevalence of high-FAI in cancer patients (relative risk [RR]: 1.56; 95% CI: 1.23-1.97) compared to noncancer patients. Stratified analysis based on times after cancer treatment revealed that patients with <5 years postcancer treatment showed a significant association with the prevalence of high-FAI (RR: 1.70; 95% CI: 1.31-2.21) compared to noncancer patients, whereas no significant association was observed between patients with ≥5 years postcancer treatment and high-FAI (RR: 1.29; 95% CI: 0.87-1.92).
conclusionsIn this population, a cancer history, especially in patients with current or recent treatment history, was significantly associated with elevated coronary inflammation.
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