ArticleJACC. Case reports2026
Thrombus on ASD Closure Device Reveals Underlying Thrombophilia.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundTranscatheter closure of atrial septal defects (ASDs) is indicated to prevent paradoxical embolism, and major complications are uncommon. However, even a small risk of thrombus formation can be amplified by an underlying thrombophilia. CASE SUMMARY: A 25-year-old woman with a history of embolic stroke underwent transcatheter ASD closure. Three years later, she presented with another stroke and was found to have thrombus on the closure device. She was started on long-term anticoagulation, and follow-up imaging showed resolution of the thrombus. Further evaluation revealed antiphospholipid syndrome, an autoimmune thrombophilia. DISCUSSION: This case highlights the importance of ruling out hypercoagulable conditions in patients with a thromboembolic event such as a stroke before ASD closure. In patients with underlying thrombophilia, a closure device may increase the risk of thrombus formation and contribute to future embolic events rather than preventing them. TAKE-HOME MESSAGES: Thorough thrombophilia screening should be considered before ASD closure in patients with embolic stroke. Undiagnosed hypercoagulable states may increase the risk of late-onset device-related thrombosis.
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