SynthesisAnnals of medicine2025
The lung immune prognostic index as a predictive biomarker in urological malignancies undergoing immune checkpoint inhibitor therapy.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
objectiveWe conducted a meta-analysis to evaluate the prognostic utility of the Lung Immune Prognostic Index (LIPI) in patients with urological malignancies treated with immune checkpoint inhibitors (ICIs).
methodsWe systematically searched PubMed, the Cochrane Library, and EMBASE up to March 3, 2025. Clinical outcomes included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR). Study quality was assessed using the Newcastle-Ottawa Scale (NOS), with a threshold score ≥6 defining high-quality studies.
resultsThis meta-analysis incorporated seven studies comprising 2498 patients. Our findings demonstrated that patients with good LIPI index exhibited significantly prolonged OS (good vs. intermediate: HR = 0.51, 95% CI 0.42-0.62,
conclusionThe LIPI emerges as a valuable prognostic biomarker in patients with urological malignancies treated with ICIs therapy.
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