ReviewMicrobiology and molecular biology reviews : MMBR2025
Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants.
Review in Microbiology and molecular biology reviews : MMBR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Pyrazole-Derived Antibacterial Compounds Effectively Treat Methicillin-Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- How resistance-nodulation-division (RND) efflux pumps contribute to virulence.PLoS pathogens · 2026Review
- Berberine Attenuates Chromobacterium violaceum's Virulence by Targeting Efflux and Denitrification Machinery.Chemistry & biodiversity · 2026Article
- AcrAB-NodT overexpression drives envelope destabilization and metal sensitivity in Caulobacter vibrioides.Archives of microbiology · 2026Review
- Hybrid capture RNA-seq defines temporal gene expression inbioRxiv : the preprint server for biology · 2026Article
- A correlation analysis between arsenic and mercury resistance and the spread of antibiotic resistance genes in bacteria isolated from a highly contaminated brownfield.Frontiers in microbiology · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
SUMMARYEarly in evolution, cells acquired the ability to use energy to export waste and toxic products against a concentration gradient. In Gram-negative bacteria, the resistance-nodulation-cell division (RND) superfamily of multi-subunit efflux pumps transport toxic molecules to the extracellular milieu. RND efflux pumps require cell-membrane proton motive force to export a wide range of substrates. Within the RND superfamily, Hydrophobe/Amphiphile Efflux 1 (HAE-1) family members have been studied extensively for their critical role in exporting structurally diverse antibiotics and, consequently, their contributions to multidrug resistance. However, HAE-1 RND efflux pumps are also required for pathogen survival in the mammalian host when antibiotics are absent. Here, we investigate the role of HAE-1 RND efflux pumps as virulence determinants. We analyze the genetic evidence that Gram-negative bacterial pathogens require HAE-1 RND efflux pumps to cause infection and briefly discuss the development of therapeutic and prophylactic approaches to interfere with HAE-1 RND efflux pump activity as a complement to existing antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.