Evidence map›Paper›PMID 41263494›Full record

ArticleClinical and experimental dental research2025

Pyrophosphate Regulates Multilineage Differentiation in Stem Cells From Human Exfoliated Deciduous Teeth.

Ravipha Suwittayarak, Nunthawan Nowwarote, Chatvadee Kornsuthisopon, Waleerat Sukarawan, Brian L Foster, Hiroshi Egusa, Thanaphum Osathanon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ravipha SuwittayarakCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Nunthawan NowwaroteDepartment of Oral Biology, Faculty of Dentistry, Université Paris Cité, Paris, France.ORCID 0000-0001-5315-5565
Chatvadee KornsuthisoponCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Waleerat SukarawanCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Brian L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-3444-0576
Hiroshi EgusaDivision of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan.
Thanaphum OsathanonCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.ORCID 0000-0003-1649-6357

Funding

R.S. was supported by the Second Century Fund, Chulalongkorn University (C2F Ph.D. scholarship) and the 90th Anniversary of Chulalongkorn University Scholarship. T.O. was supported by the Faculty Research Fund, Faculty of Dentistry, Chulalongkorn University.
6 · The paper itself

Abstract

backgroundTo explore the cellular behavior of stem cells derived from human exfoliated deciduous teeth (SHED) in response to inorganic pyrophosphate (PP MATERIALS AND

methodsSHED cells were isolated from the dental pulp tissues of human primary exfoliated teeth. Cell proliferation was examined using the MTT assay, colony-forming unit assay, and cell cycle analysis. Cell migration was evaluated using the scratch assay. Osteogenic differentiation was assessed by the expression of osteogenic marker genes and in vitro mineral deposition. Oil Red O staining was employed to determine intracellular lipid accumulation under adipogenic differentiation. For osteoclast differentiation, TRAP staining was used. The global gene expression profile was examined by RNA sequencing analysis.

resultsPP

conclusionPP

Indexed as

Cell DifferentiationCell LineageDiphosphatesStem CellsTooth, DeciduousAdipogenesisApoptosisCell MovementCell ProliferationCells, CulturedDental PulpHumansOsteogenesisTooth ExfoliationDiphosphatesdiphosphoric acidbone remodellingdifferentiationpyrophosphatesequencingtooth

Identifiers

PMID41263494
PMCPMC12631897

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.