ReviewCurrent opinion in rheumatology2026
Spatial transcriptomics: challenges and future directions in musculoskeletal diseases.
Review in Current opinion in rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Epigenetic regulation in osteoarthritis: recent updates and emerging mechanisms.Frontiers in genetics · 2026Review
- Translating Osteoarthritis Genetic Risk Into Biomarkers: Opportunities, Pitfalls, and Implementation Considerations.Human mutation · 2026Review
- Transcriptomics and AI-driven approaches to the diagnosis and treatment of rheumatoid arthritis.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis review examines recent advancements in spatial transcriptomics and its current and potential use to advance musculoskeletal (MSK) research. These insights will be vital to address the complexity of MSK diseases and will pave the way for future therapeutic developments. RECENT
findingsThe advent of next-generation sequencing has significantly improved our understanding of the cellular and transcriptomic heterogeneity in the MSK system. Spatial transcriptomics has revolutionized research allowing in-situ gene expression analyses directly from intact histological sections. Understanding spatial transcriptomes of cells within tissues will shed light into the biological complexity of MSK diseases. Here, we summarize the role of spatial transcriptomics in unveiling molecular mechanisms underlying MSK diseases and the challenges prohibiting its widespread application in MSK research, and opportunities to overcome these challenges. SUMMARY: We provide a summary of emerging techniques in spatial transcriptomic field and its use in advancing MSK research. Furthermore, challenges in its application in MSK tissues are discussed as well as potential future considerations to improve spatial transcriptomics insights.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.