Evidence map›Paper›PMID 41263389›Full record

ArticleClinical endocrinology2026

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities.

Denise Costa, Giada Giuliani, Valentina Martines, Chiara Pellicano, Valeria Mercuri, Vittorio Di Piero, Patrizia Gargiulo, Camilla Virili

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Denise CostaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-9583-853X
Giada GiulianiDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Valentina MartinesNeuroradiology Division, Sapienza University of Rome, Rome, Italy.
Chiara PellicanoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Valeria MercuriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Vittorio Di PieroDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Patrizia GargiuloDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Camilla ViriliMedicosurgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

introductionAcromegaly is a rare chronic disease caused by excessive secretion of growth hormone. Even with biochemical control, hormonal imbalance may lead to cerebral changes. This study aimed to evaluate the presence of white matter hyperintensities (WMHs) in patients with acromegaly. MATERIALS AND

methodsWe retrospectively enrolled 37 acromegaly patients who underwent gadolinium-enhanced brain MRI to detect WMHs and their distribution. We analysed potential contributing factors such as cardiovascular comorbidities, migraine, inflammatory markers (plasma interleukin-33), and hand skin perfusion using laser speckle contrast analysis.

resultsWMHs were found in 24 patients (64.9%), with nine showing a higher lesion burden. Patients with WMHs were older [63 years (IQR 47.5-67.5) versus 48 years (IQR 44-53), p = 0.023] and had a longer disease duration [19 years (IQR 11.5-26.5) versus 13 years (IQR 12-15), p = 0.028] than those without WMHs. Hypertension (22/37) and migraine (18/37) were the most common comorbidities. A higher WMH burden was significantly associated with hypertension (p = 0.05), while no significant link was found between WMHs and migraine (p > 0.05).

conclusionSeveral factors in acromegaly may affect brain structure, promoting WMH development, such as aging, disease duration, and hypertension. Therefore, in patients with acromegaly, we suggested the early management of cardiovascular comorbidities and regular radiological follow-up, not limited to the study of the pituitary gland. Future prospective studies are necessary to confirm our preliminary observations and to clarify the potential role of disease activity and treatment in WMH development.

Indexed as

AcromegalyBrainWhite MatterAdultAgedFemaleHumansHypertensionMagnetic Resonance ImagingMaleMiddle AgedRetrospective Studiesacromegalyhypertensioninflammationmigrainewhite matter hyperintensities

Identifiers

PMID41263389
PMCPMC12865734

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