Evidence map›Paper›PMID 41263386›Full record

ArticleInternational journal of cancer2026

Cancer risks and trends between 1997 and 2018, and effects of restored immunity in people living with HIV: Results from the ANRS CO4 French hospital database on HIV.

Sophie Grabar, Paula Lakrout, Valérie Potard, Aurélien Belot, Jacques Cadranel, Christine Jacomet, Christine Katlama, Esaïe Marshall, Olivier Lambotte, Romain Palich and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sophie GrabarSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Paris, France.ORCID https://orcid.org/0000-0002-4816-4261
Paula LakroutSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Valérie PotardSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Aurélien BelotInequalities in Cancer Outcomes Network (ICON), Department of Health Services Research and Policy, Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0003-1410-5172
Jacques CadranelAP-HP, Hôpital Tenon, Service de Pneumologie et Oncologie Thoracique, GRCO4 Theranoscan, Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0003-2446-2923
Christine JacometInfectious Diseases Department, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
Christine KatlamaSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Esaïe MarshallSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Olivier LambotteUniversité Paris Saclay, AP-HP, Service de Médecine Interne Immunologie Clinique, Hôpital de Bicêtre, Inserm, Le Kremlin Bicêtre, France.
Romain PalichSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
Sylvie Ronot-BregigeonAPHM, Hôpital Sainte-Marguerite, Aix-Marseille Université, Marseille, France.
Jean-Philippe SpanoSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Paris, France.
Anne-Marie BouvierDigestive Cancer Registry of Burgundy, Dijon, France.ORCID https://orcid.org/0000-0001-9070-1027
Alain MakinsonCHU Montpellier, Service de Maladies Infectieuse et tropicale, Université de Montpellier, Montpellier, France.
Dominique CostagliolaSorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.

Funding

Agence Nationale de Recherche sur le Sida et les hépatites virales-Maladies Infectieuses Emergentes n°ECTZ115869
6 · The paper itself

Abstract

We assessed long-term trends in cancer incidence among people with HIV (PWH) in France between 1997 and 2018, focusing on AIDS-defining cancers (ADC) (Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer), three virus-related non-AIDS-defining cancers (Hodgkin lymphoma, liver, and anal cancer), and four virus-unrelated cancers (lung, colorectal, prostate, and breast cancer). Using data from the ANRS CO4-French Hospital Database on HIV and cancer registries in the general population, we calculated age-standardized incidence rates and standardized incidence ratios (SIRs) across four time periods. Special attention was given to PWH with controlled viral load and restored CD4 during 2008-2018. Among 154,733 individuals contributing nearly 2 million person-years, 9572 cancers were diagnosed. Incidence rates of ADC and virus-related non-ADC declined over time but remained significantly higher than in the general population, with SIRs ranging from 3 to 420, even in recent years. Rates of prostate and colorectal cancers increased overtime, while breast cancer incidence remained stable. For these three cancers, the relative risk compared to the general population remained close to 1. In PWH with CD4 ≥ 500/mm

Indexed as

HIV InfectionsNeoplasmsAdultAgedDatabases, FactualFemaleFranceHumansIncidenceMaleMiddle AgedRegistriesRisk FactorsViral Loadcancercohortgeneral populationHIV/AIDSmalignancy

Identifiers

PMID41263386
PMCPMC12963702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.