SynthesisMicrobiologyOpen2025
Comparison of Gut Microbiological Profiles of Inbred and Outbred Healthy Mice.
Synthesis in MicrobiologyOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Comparison of Gut Microbiological Profiles of Inbred and Outbred Healthy Mice.MicrobiologyOpen · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Gut microbes are closely related to host immunity and health, and mice are frequently used as a common model organism in biomedicine to study various diseases. Numerous studies based on mouse gut microbes have been conducted, but whether there are differences in the gut microbial profiles of healthy mice of different strains has not been revealed. In this study, we performed a meta-analysis comparing four strains (inbred strains: C57BL and BALB; outbred strains: KM and ICR) of mouse healthy gut microbial 16S V3-V4 data based on publicly available online data. We focused on microbial diversity, microbial composition, abundance differential microbiota, and co-abundance networks. We found that the gut microbes of these four strains of mice differed in the above metrics to varying degrees. Our study found significant differences in gut microbiology among four strains of healthy mice. The strain will be a background factor that cannot be ignored in future studies of gut microbiology in mice. The impact of this factor on gut microbiology experiments should be considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.