Evidence map›Paper›PMID 41263126›Full record

ArticleCancer medicine2025

Management and Prognostic Implications of Posteriorly Advanced OSCC in Contact With the Medial Pterygoid Muscle.

Nanako Ito, Fumitaka Obayashi, Mirai Higaki, Atsuko Hamada, Sachiko Yamasaki, Tomoaki Shintani, Toshinori Ando, Koichi Koizumi, Souichi Yanamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nanako ItoDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID https://orcid.org/0000-0002-1933-7274
Fumitaka ObayashiDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Mirai HigakiDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Atsuko HamadaDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Sachiko YamasakiDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Tomoaki ShintaniCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan.
Toshinori AndoCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan.ORCID https://orcid.org/0000-0002-3141-8173
Koichi KoizumiDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Souichi YanamotoDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT4b was previously defined as unresectable; however, it has been demonstrated that compartmental surgery can achieve treatment outcomes comparable to those of T4a cases. We frequently encounter posteriorly advanced oral squamous cell carcinoma (OSCC) in contact with the medial pterygoid muscle, and determining the appropriate extent of resection and managing subsequent recurrence in the masticator space remain challenging. Therefore, this study aimed to investigate the association between the tumor's spatial relationship with the medial pterygoid muscle and patient outcomes, providing insights to enhance diagnostic precision and guide therapeutic strategies.

methodsThis retrospective study included 50 patients with posteriorly advanced OSCC, excluding those classified as T4b. Preoperative magnetic resonance imaging classified lesions as either non-contact or contact type based on their relationship to the medial pterygoid muscle. Clinicopathological factors, overall survival rate (OS), and recurrence rates in the masticator space were compared between the two groups.

resultsNo significant differences were observed in OS between the non-contact and contacttypes. Among non-contact types, no recurrence in the masticator space was observed, whereas contact-type tumors showed a recurrence rate of 22.6% (p = 0.04). Multivariate analysis revealed that lymphatic invasion was associated with an increased risk of primary recurrence, whereas postoperative radiotherapy was associated with a reduced risk among 31 patients with contact-type tumors.

conclusionsIn summary, compartmental surgery with pterygomandibular space dissection should be considered for contact-type tumors near the medial pterygoid muscle, along with T4b cases. However, its indication must be assessed based on clinical findings. Postoperative radiotherapy is key to recurrence prevention, improving oncologic outcomes and long-term disease control.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsPterygoid MusclesSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective Studiescompartmental surgerymasticator spacemedial masticator space dissectionoral squamous cell carcinomapostoperative radiotherapy (PORT)recurrencesurvival

Identifiers

PMID41263126
PMCPMC12631172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.