Evidence map›Paper›PMID 41263099›Full record

ArticleNucleic acids research2026

The PROSITE database for protein families, domains, and sites.

Christian J A Sigrist, Béatrice A Cuche, Edouard de Castro, Elisabeth Coudert, Nicole Redaschi, Alan Bridge

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christian J A SigristSwiss-Prot Group, Swiss Institute of Bioinformatics (SIB), Centre Médical Universitaire (CMU), 1 rue Michel Servet, CH-1211Geneva 4, Switzerland.ORCID 0000-0002-4348-0070
Béatrice A CucheSwiss-Prot Group, Swiss Institute of Bioinformatics (SIB), Centre Médical Universitaire (CMU), 1 rue Michel Servet, CH-1211Geneva 4, Switzerland.ORCID 0000-0003-4364-6779
Edouard de CastroSwiss-Prot Group, Swiss Institute of Bioinformatics (SIB), Centre Médical Universitaire (CMU), 1 rue Michel Servet, CH-1211Geneva 4, Switzerland.ORCID 0000-0001-5436-7383
Elisabeth CoudertSwiss-Prot Group, Swiss Institute of Bioinformatics (SIB), Centre Médical Universitaire (CMU), 1 rue Michel Servet, CH-1211Geneva 4, Switzerland.ORCID 0000-0001-8314-404X
Nicole RedaschiSwiss-Prot Group, Swiss Institute of Bioinformatics (SIB), Centre Médical Universitaire (CMU), 1 rue Michel Servet, CH-1211Geneva 4, Switzerland.ORCID 0000-0001-8890-2268
Alan BridgeSwiss-Prot Group, Swiss Institute of Bioinformatics (SIB), Centre Médical Universitaire (CMU), 1 rue Michel Servet, CH-1211Geneva 4, Switzerland.ORCID 0000-0003-2148-9135

Funding

State Secretariat for Education, Research and Innovation
6 · The paper itself

Abstract

PROSITE (https://prosite.expasy.org/) is a database of entries documenting protein domains, families, and functional sites, along with the associated patterns and profiles used to identify them. It is complemented by ProRule, a rule collection that enhances the discriminatory power of these profiles and patterns by providing additional information about amino acids critical for function and/or structure. Together, PROSITE motifs and ProRules are used to annotate domains and features in UniProtKB/Swiss-Prot entries. Since the onset of the COVID-19 pandemic, PROSITE has contributed to SARS-CoV-2 research by leveraging existing tools and by developing new profiles and ProRules for SARS-CoV-2 protein domains. A newly developed profile has also uncovered a link between coregulators of two transcription factor families: POU2F and NF-κB. ProRule has been updated to incorporate the ChEBI ontology to describe chemical ligands and the Rhea reference vocabulary for biochemical reaction annotation. Predicted tridimensional (3D) structures from AlphaFold are now regularly used to define domain boundaries during profile construction. ScanProsite has been enhanced to allow users to visualize motif matches on AlphaFold-predicted structures. In addition, the original pfsearch code has been fully rewritten and optimized to make efficient use of modern multi-core processors, with a new heuristic implemented to further improve performance.

Indexed as

Databases, ProteinProtein DomainsProteinsViral ProteinsCOVID-19HumansSARS-CoV-2ProteinsViral Proteins

Identifiers

PMID41263099
PMCPMC12807641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.