Evidence map›Paper›PMID 41263085›Full record

ArticleStroke2026

Prevalence, Predictors, and Prognosis of Depression After Transient Ischemic Attack: A Population-Based Study.

Aubretia J McColl, Ramon Luengo-Fernandez, Emily-Rose Vaughan-Fowler, Matthew B Downer, Sarah T Pendlebury, Lucy E Binney, Louise E Silver, Peter M Rothwell, Oxford Vascular Study

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aubretia J McCollNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0001-5426-5344
Ramon Luengo-FernandezNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0002-2118-2662
Emily-Rose Vaughan-FowlerNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0002-6965-7559
Matthew B DownerNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0003-1838-2476
Sarah T PendleburyNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0003-3603-8388
Lucy E BinneyNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0003-2131-5338
Louise E SilverNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0002-4872-621X
Peter M RothwellNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.ORCID 0000-0001-9739-9211
Oxford Vascular StudyNuffield Department of Clinical Neurosciences, Wolfson Centre for the Prevention of Stroke and Dementia, Wolfson Building-John Radcliffe Hospital, University of Oxford, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is common after stroke and is associated with increased mortality. However, there are few data on the prevalence, predictors, or prognosis of depression after transient ischemic attack (TIA). Although poststroke depression is often assumed to be due to the brain lesion or disability, patients with TIA may also be susceptible due to shared risk factors, lifestyle/medication changes, or worries about stroke.

methodsThe prevalence of depression 1 and 12 months after TIA was assessed in a population-based cohort (OXVASC [Oxford Vascular Study]) from 2014 to 2020. Depression was related to risk factors (including infarction on brain imaging) in a multivariable logistic regression model and outcome (disability, quality of life, institutionalization, recurrent events, and mortality) in a Cox proportional hazard regression model during 5-year follow-up after adjustment for covariates that were found to be significant (

resultsOf 519 patients (mean age, 70.5 [13.1]; female, 51.1%), 126 (24.3%) had depression after TIA, with a higher rate at 1 versus 12 months (99/20.7% versus 66/14.9%;

conclusionsDepression is common early after TIA, independent of acute ischemia on brain imaging, and persistent depression is also strongly associated with adverse outcomes.

Indexed as

DepressionIschemic Attack, TransientAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedPrevalencePrognosisQuality of LifeRisk Factorscerebral infarctiondepressionischemic attack, transientprognosisstroke

Identifiers

PMID41263085
PMCPMC12721673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.