ArticleLifestyle genomics2026
Impact of Hypoxia-Inducible Factor-1α Gene Polymorphisms on Renal Cell Carcinoma Susceptibility in a Chinese Han Population.
Article in Lifestyle genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPrevious studies have reported the impact of the hypoxia inducible factor-1α (HIF1α) gene on risk of renal cell carcinoma (RCC). However, the results of these previous studies were inconsistent. Hence, this study aimed to verify the influence of single-nucleotide polymorphisms (SNPs) in the HIF1α gene and their interaction with environmental factors on RCC risk.
methodsPCR-based restriction fragment length polymorphism was used to genotype four SNPs. Logistic regression was utilized to test the association between HIF1α SNPs and RCC risk. A generalized multifactor dimensionality reduction model was employed to evaluate the potential interaction of the four SNPs in the HIF1α gene with environmental factors.
resultsThe rs11549465-CT, rs11549465-TT, and rs11549465-CT+TT genotypes were all associated with increased risk of RCC; the adjusted ORs (95% CI) were 1.74 (1.38-2.12) (CT vs. CC), 1.93 (1.47-2.43) (TT vs. CC), and 1.78 (1.41-2.18) (CT+TT vs. CC), respectively. We also found that the rs11549467-GA and rs11549467-GA+AA genotypes were associated with increased RCC risk, and adjusted ORs (95% CI) were 1.81 (1.49-2.16) (GA vs. GG), 1.79 (1.47-2.13) (GA+AA vs. GG), respectively. We found a statistically significant combination (including rs11549465 and smoking). Compared to non-smokers with the rs11549465-CC genotype, current or ever smokers with rs11549465-CT+TT genotype had the highest RCC risk; the OR (95% CI) was 3.68 (1.97-5.41).
conclusionThis study demonstrated a significant impact of HIF1α polymorphisms on RCC risk. Additionally, this impact could be influenced by environmental factors, such as smoking status.
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