Evidence map›Paper›PMID 41263030›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m

Ling Li, Yong-Dong Guo, Xiao-Wen Zhang, Zhi-Yong Du, Yu-Qi Wang, Zhuo Yang, Qian-Wei Luo, Fang-Fang Zhuo, Tian-Tian Wei, Zheng-Ping Liu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Pharmacological modulation of stress granulesFrontiers in pharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ling LiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Yong-Dong GuoDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Xiao-Wen ZhangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhi-Yong DuKey Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, National Clinical Research Center for Cardiovascular Diseases, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yu-Qi WangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhuo YangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Qian-Wei LuoState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Fang-Fang ZhuoState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Tian-Tian WeiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zheng-Ping LiuShandong Engineering Research Center of New Sustained and Controlled Release Formulations and Drug Targeted Delivery Systems, Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Bo HanSchool of Pharmacy/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi University, Shihezi, 832003, China.
Wei YuSchool of Pharmacy/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi University, Shihezi, 832003, China.
Pei-Pei ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Wei ZhouState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Zhi-Yuan LuSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Peng-Fei TuState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Chun-Hong ZhengDepartment of Immunology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Ke-Wu ZengState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.ORCID https://orcid.org/0000-0003-1082-6327

Funding

Jinan New 20 Policies for Higher Education Funding 202228048National Natural Sciences Foundation of China 82325050 82174008Natural Science Foundation of Shandong Province ZR2022LZY021The Special Fund for Taishan Scholars Project in Shandong Province tstp20230633
6 · The paper itself

Abstract

Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) mediates stress granules (SGs) via phase separation. However, there is limited understanding of the allosteric mechanism and the identification of regulatory molecules. Here, we identify icariin (ICA), a small-molecule inducer that promotes G3BP1-driven biomolecular condensate formation, which effectively restructures SGs architecture. Moreover, we demonstrate that ICA interacts with the N-terminal nuclear transport factor 2-like (NTF2L) domain of G3BP1, inducing a conformational switch from "closed-to-open" that facilitates G3BP1 oligomerization and phase separation. Crucially, G3BP1 condensates recruit N

Indexed as

AdenosineDNA HelicasesIschemic StrokePoly-ADP-Ribose Binding ProteinsRNA-Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsStress GranulesAnimalsDisease Models, AnimalFlavonoidsHumansMaleMiceMice, Inbred C57BLAdenosineDNA HelicasesFlavonoidsG3BP1 protein, humanG3bp1 protein, mouseIGF2BP1 protein, humanN-methyladenosinePoly-ADP-Ribose Binding ProteinsRNA-Binding ProteinsRNA HelicasesRNA Recognition Motif Proteinscondensate topologym6Aphase separationras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1)stress granules (SGs)

Identifiers

PMID41263030
PMCPMC12866838

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.