ReviewFrontiers in neurology2025
The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Fluorescent Biosensor for Rapid and Accurate Detection of Dopamine Based on Oxidized Single-Walled Carbon Nanohorns and Cryonase Enzyme.Molecules (Basel, Switzerland) · 2026Article
- Parkinson's Disease: Conventional Pharmacotherapy, Drug Delivery Innovations, and Emerging Therapeutic Targets.Brain sciences · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dopaminergic imaging has become a pivotal tool in the diagnosis of Parkinson's disease (PD) and related disorders. Its ability to assess presynaptic dopamine transporter function provides crucial insights for distinguishing PD from other acquired neurological disorders. Recent advances have also demonstrated its utility in evaluating diseases beyond PD, including non-degenerative conditions associated with parkinsonism. Objectives: This review aims to explore the diagnostic and therapeutic value of dopaminergic imaging across a range of acquired disorders, including normal pressure hydrocephalus, Holmes tremor, vascular parkinsonism, infectious and metabolic diseases as well as autoimmune encephalopathies with a particular focus on its clinical implications, imaging patterns and predictive value for treatment response. We excluded drug induced conditions as they have been extensively reviewed previously. Methods: A comprehensive systematic literature search focusing on studies that utilized dopaminergic imaging techniques was conducted in PubMed. We used the terms "DaTScan." "Dopaminergic imaging," "dopamine transporter," "Single-photon emission computed tomography," "FP CIT 123 SPECT," " Results: Dopaminergic imaging revealed variable deficits across acquired disorders, with distinct patterns aiding in the differential diagnosis. In normal pressure hydrocephalus, imaging often shows a reduction in striatal dopamine transporter binding which was reversed post-shunt surgery, distinguishing it from neurodegenerative parkinsonisms. In Holmes tremor, significant presynaptic dopaminergic deficits were associated with levodopa responsiveness. Vascular parkinsonism exhibited more diffuse and symmetric dopamine transporter reductions compared to idiopathic PD, correlating with poorer levodopa response. Conclusion: Dopaminergic imaging plays a crucial role in differentiating PD from acquired diseases presenting with parkinsonism. Its diagnostic utility, combined with clinical and pathological findings, enhances therapeutic decision-making, particularly in more common conditions like normal pressure hydrocephalus, Holmes tremor and vascular parkinsonism. As imaging techniques continue to evolve, their integration into clinical practice will further support personalized treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.