ArticleFrontiers in microbiology2025
Novel cytomegalovirus variants in immunocompromised hosts: genetic insights and clinical significance.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Human cytomegalovirus (HCMV) is a significant opportunistic pathogen affecting immunocompromised individuals, particularly solid organ and hematopoietic stem cell transplant recipients. The emergence of mutations within conserved genomic regions of HCMV genes targeted by antiviral therapies, significantly complicating the interpretation of resistance and treatment decisions. Although the molecular characterization of such mutations and their clinical correlation are critical to guide appropriate therapeutic strategies, the significance of many detected mutations and variants, even those in conserved regions, remain uncertain in terms of Methods: Clinical specimens from immunocompromised and transplant patients with confirmed HCMV DNAemia were sequenced for Results: In total, 13 patients (25%) exhibited novel Conclusion: Interpreting cytomegalovirus (HCMV) drug resistance mutations requires a comprehensive approach that integrates molecular data with clinical context. Early genotypic analysis can guide antiviral therapy; however, improved classification of mutations based on predicted resistance potential and phenotypic characteristics may optimize clinical decision-making. These insights emphasize the need for personalized management strategies in immunocompromised patients.
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