ArticleFrontiers in pediatrics2025
Congenital tuberculosis in preterm infants in a high-burden setting in southwest China: a single-center cross-sectional study.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Congenital tuberculosis (CTB) is an extremely rare and potentially life-threatening infection in premature infants that is frequently misdiagnosed. There is still a lack of thorough characterization of this condition in preterm neonates, particularly in high TB-burden settings. Methods: Premature infants with CTB were identified from hospital medical records from January 2016 to December 2023 in a high-burden, resource-limited neonatal intensive care unit (NICU) in southwest China. Diagnosis was based on etiology and clinical evidence. Data extracted included demographics, maternal history of tuberculosis (TB) exposure, symptoms, laboratory markers, microbiological findings, imaging findings, treatment regimens, and prognosis. These were evaluated during the pre-diagnosis, diagnosis, and posttreatment stages. Results: A total of 11 premature infants with CTB were included. Maternal TB was common in this cohort; 7 of the 11 mothers were diagnosed with TB following Conclusions: In this study, preterm infants with CTB frequently demonstrated non-specific clinical signs with a reversible pattern of inflammation, anemia, thrombocytopenia, and electrolyte disturbances that normalized after anti-TB therapy. These patterns, together with maternal TB risk or
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