Evidence map›Paper›PMID 41262910›Full record

ReviewPatient preference and adherence2025

Pharmacist-Led Interventions to Improve Medication Adherence Among Patients with Multimorbidity: A Scoping Review.

Shofuro Sholihah, Fima Perdani Rahayu, Lubna Farhana, Sameer Alshehri, Sofa Dewi Alfian, Rizky Abdulah

Abstract readReview
In one paragraph

Review in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shofuro SholihahDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.
Fima Perdani RahayuDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.ORCID 0009-0005-0732-8222
Lubna FarhanaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.ORCID 0009-0005-2836-0969
Sameer AlshehriDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Sofa Dewi AlfianDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.ORCID 0000-0001-5419-8938
Rizky AbdulahDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with multimorbidity tend to have multiple medications or polypharmacy to achieve optimal outcomes, which may result in non-adherence to medication. Medication non-adherence in this population is relatively higher than in patients with a single disease because of more complex medication regimens and greater adverse drug reactions. Providing interventions is an essential solution in changing patients' behavior towards medication adherence among patients with multimorbidity. Pharmacists could help patients achieve optimal outcomes by optimizing medication use, including improving medication adherence. This scoping review aims to identify evidence of the effectiveness and characterize pharmacist-led interventions in improving medication adherence among patients with multimorbidity. Methods: A systematic search was conducted to identify relevant studies on PubMed, Scopus, CENTRAL, and through hand searching. Randomized controlled trial design studies performing interventions to improve medication adherence led by pharmacists among patients living with multimorbidity were included. We focused on original search with the key concepts of "multimorbidity", "pharmacists", and "medication adherence". Narrative synthesis was used to extract and synthesize the data. Results: Twelve studies that included participants with multimorbidity were reviewed. Nine of all twelve studies showed improvement of medication adherence in the intervention group with a p-value <0.05, while three other studies indicated no significant difference between the intervention and control groups. All of the studies employed personalized interventions. Interventions used could be divided into counselling sessions, medication management, or using a supporting tool as a reminder of drug administration. Conclusion: In nine out of twelve studies, interventions led by pharmacists were found to be effective in improving medication adherence in patients with multimorbidity. Effective interventions showed significant improvement in medication adherence in the intervention group compared with the usual care group. These interventions included counselling sessions, medication management, and the use of a supporting tool to remind patients about drug administration.

Indexed as

interventionmedication adherencemultimorbiditypharmacists

Identifiers

PMID41262910
PMCPMC12626026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.