ArticleCureus2025
Correlation of the Six-Minute Walk Test, Diffusing Capacity for Carbon Monoxide, and Pulmonary Function Parameters in Patients With Interstitial Lung Disease: A Cross-Sectional Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Interstitial lung disease (ILD) encompasses a broad group of progressive lung disorders marked by inflammation and fibrosis, leading to irreversible damage. Early screening plays a pivotal role in identifying disease onset and optimizing patient outcomes. This study assessed the correlation of diffusing capacity for carbon monoxide (DLCO) with the six-minute walk test (6-MWT) and pulmonary function test (PFT) parameters. Moreover, the correlation between 6-MWT and PFT parameters was evaluated. Methods This cross-sectional study, involving 30 patients with high-resolution computed tomography-proven ILD, was performed over a period of 24 months (October 2022 to September 2024) in the Department of Respiratory Medicine of Government Medical College, Nagpur, in Nagpur, India. All patients underwent 6-MWT and PFT. Vital parameters were assessed before and immediately after 6-MWT, and the six-minute walk distance (6-MWD) was calculated. Results 6-MWT had a weakly positive and significant correlation with forced vital capacity (FVC) (r=0.38; p=0.037), but not with forced expiratory volume in one second (FEV1) and DLCO (p>0.05). DLCO had a positive and non-significant correlation with total lung capacity, FEV1, and FVC, while correlation with FEV1/FVC ratio was negative and non-significant (p>0.05). Actual 6-MWD was significantly lower than the predicted value (p<0.001). Immediately after 6-MWT, there was a significant decrease in oxygen saturation, while systolic blood pressure, pulse rate, and respiratory rate increased significantly compared to baseline 6-MWT values (p<0.001), with diastolic blood pressure being comparable at both intervals (p>0.05). Conclusion 6-MWT had a weak but significant correlation with FVC, while the correlation between other parameters was not significant. These tests highlight functional limitations and physiological derangements, thus strengthening their role in ILD management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.