ArticleFrontiers in nutrition2025
Association of plasma carnitine levels with bone mineral density and recent osteoporotic fracture.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The carnitine system may play an essential role in bone metabolism. However, existing epidemiological studies on the association between carnitine and bone mineral density (BMD) are still controversial. No human study has examined the association of carnitine and osteoporotic fracture. The objective of this research was to examine the association of carnitine levels with BMD and recent osteoporotic fracture. Methods: We used cross-sectional and case-control studies to examine the associations of carnitine levels with BMD and recent osteoporotic fracture. The cross-sectional study identified 135 participants aged ≥45 years from the Second Hospital of Jilin University. The case-control study identified 44 recent fracture cases and 88 healthy controls aged 50 and older. Multivariable linear regression models were used to test the associations of carnitine with BMD, and conditional logistic regression models were used to analyze the association between carnitine levels and fracture. We used targeted metabolomics technology to measure 27 types of plasma carnitine levels. Results: In the cross-sectional study, the average age was 57.6 ± 5.0 years, with 29 participants (21.5%) being female. We observed no significant association between total carnitine levels and BMD ( Conclusion: Carnitine was not associated with BMD but was negatively associated with osteoporotic fracture. The low carnitine levels among fracture cases may be due to the post-fracture inflammatory and catabolic stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.