ArticleFrontiers in nutrition2025
Modified geriatric nutritional risk index: a high-sensitivity marker with L-shaped association for sarcopenia in hospitalized older adults.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Screening for sarcopenia in older inpatients is currently inadequate, primarily because of the lack of consideration of the interaction between inflammation and nutrition. This study aimed to assess the efficacy of a novel modified Geriatric Nutritional Risk Index (mGNRI), which incorporates C-reactive protein (CRP) levels and weight changes, in predicting sarcopenia compared to traditional indices (geriatric nutritional risk index, GNRI/nutritional risk index, NRI). Methods: In this cross-sectional study, we evaluated 153 hospitalized older patients (mean age, 80.2 ± 9.1 years) using comprehensive assessments. Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia (AWGS) criteria, which include muscle mass and strength/function. We analyzed the associations using restricted cubic splines and multivariable logistic regression and compared the diagnostic performance using receiver operating characteristic (ROC) analysis. Results: The prevalence of sarcopenia was 24.2% (37/153). The mGNRI was significantly lower in the sarcopenia group compared to the non-sarcopenia group (48.1 ± 11.3 vs. 56.8 ± 12.8, * Conclusion: The mGNRI serves as a practical and inflammation-sensitive tool for screening for sarcopenia in older inpatients. Its L-shaped association highlights a critical intervention threshold (mGNRI<55), demonstrating superior sensitivity compared to the linear indices (GNRI, NRI). Incorporating this tool into geriatric assessments may facilitate targeted interventions to address nutritional and inflammatory needs.
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