Evidence map›Paper›PMID 41262706›Full record

ArticleImmunity & inflammation2025

Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function.

Xiangyi Deng, Weijie Du, Gilles Gasparoni, Abdulrahman Salhab, Karl Nordström, Jinchan Li, Viktoria Wagner, Erping Zhang, Joachim Wachtlin, Juliane Bodo and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Xiangyi Deng *Department of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Weijie Du *Department of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Gilles Gasparoni *Department of Genetics, University of Saarland, Saarbrücken, Germany.
Abdulrahman Salhab *Department of Genetics, University of Saarland, Saarbrücken, Germany.
Karl Nordström *Department of Genetics, University of Saarland, Saarbrücken, Germany.
Jinchan LiDepartment of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Viktoria WagnerDepartment of Genetics, University of Saarland, Saarbrücken, Germany.
Erping ZhangSankt Gertrauden Krankenhaus, Berlin, Germany.
Joachim WachtlinSankt Gertrauden Krankenhaus, Berlin, Germany.
Juliane BodoPlastische Und Ästhetische Chirurgie, Berlin, Germany.
Simon ReinkeBerlin-Brandenburg Center for Regenerative Therapies , Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Berlin, Germany.
Hong LeiShaanxi Institute for Pediatric Diseases, Xi'an Children's Hospital, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, China.
Carsten PerkaCenter for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Berlin, Germany.
Sebastian HardtCenter for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Berlin, Germany.
Thomas DörnerDepartment of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Berlin, Germany.
Christoph HolmerDepartment of General, Visceral and Vascular Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Mario TönniesRespiratory Diseases Clinic Heckeshorn, Helios Klinikum Emil Von Behring GmbH, Berlin, Germany.
Torsten BauerRespiratory Diseases Clinic Heckeshorn, Helios Klinikum Emil Von Behring GmbH, Berlin, Germany.
Hyun-Dong ChangSchwiete Laboratory for Microbiota and Inflammation, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Julia K PolanskyBerlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health; Department of Immuno-Epigenetics, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Jörn Walter *Department of Genetics, University of Saarland, Saarbrücken, Germany.
Pawel Durek *Department of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Andreas Radbruch *Department of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.
Jun Dong *Department of Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin, Institute of the Leibniz Association, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adaptive immunity relies on antibodies and memory B and T cells, with memory T cells providing "reactive memory". These cells either circulate in the blood or remain as tissue-resident memory T cells, yet the epigenetic mechanisms underlying their recall function and maintenance are not well understood. Here, we present a comprehensive analysis of 56 reduced representation bisulfite sequencing (RRBS) datasets from 22 memory CD4 and CD8 T-cell populations isolated from human bone marrow, intestine, spleen, lung, skin, and peripheral blood, including surface CD69-positive and CD69-negative cells. Our study reveals unique DNA hypomethylation patterns in tissue-resident memory T cells, particularly in regions associated with genes involved in tissue homing, residency, and transcription factors regulating recall effector memory. The methylomes and differential methylation signatures identified here serve as a valuable resource for understanding the epigenetic program of memory T lymphocytes, their roles in immunological recall, and their maintenance within specific tissues. Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s44466-025-00009-x.

Indexed as

Chemokine receptorsDNA methylationEpigenetic memoryhuman tissuesIntegrinsMaintenanceTissue-resident memory T cellsTranscription factors

Identifiers

PMID41262706
PMCPMC12623507

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