Evidence map›Paper›PMID 41262682›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)

Developing educational materials to aid in Alzheimer's blood biomarker disclosure.

Raymond R Romano, Dominic Roby, Sydney Wilhoite, Marina Velez, Angela L Jefferson, Corey J Bolton

Abstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raymond R RomanoVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville Tennessee USA.
Dominic RobyVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville Tennessee USA.
Sydney WilhoiteVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville Tennessee USA.
Marina VelezVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville Tennessee USA.
Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville Tennessee USA.
Corey J BoltonVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville Tennessee USA.

Funding

Vanderbilt Alzheimer's Disease Research CenterP20AG068082 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2020 to 2023
$5.6M
Risk factors and prevention targets for abnormal cognitive agingK24AG046373 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEFFERSON, ANGELA L. · 2014 to 2023
$1.7M
NIA NIH HHS K24 AG046373NIA NIH HHS P20 AG068082
6 · The paper itself

Abstract

introductionA crucial step before clinical use of Alzheimer's disease (AD) blood biomarkers is the development of effective methods for disclosing results. This mixed-method study developed educational materials to disclose the dementia risk based on plasma phosphorylated tau (p-tau) results.

methodsParticipants diagnosed with mild cognitive impairment (MCI;

resultsParticipants rated the materials highly regarding value and comprehension. Thematic analysis revealed confusion about dementia progression and terminology. Participants preferred varied communication modes. Participants found utility in these materials but sought additional information on risk reduction. DISCUSSION: These findings highlight the utility of educational materials to aid in the disclosure of AD dementia risk based on plasma p-tau to individuals with MCI and their loved ones. Highlights: Individuals with mild cognitive impairment (MCI) find value in receiving blood biomarker results.Additional risk reduction information is helpful when communicating dementia risk.Individuals prefer medical information communicated visually.

Indexed as

Alzheimer's diseasebiomarkersdementiahealth literacyhealth risk behaviorsmild cognitive impairment

Identifiers

PMID41262682
PMCPMC12623145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.