ArticleNanotechnology, science and applications2025
Guiding Cell Growth: Graphene-Patterned Polymeric Substrates for Enhanced Tissue Proliferation.
Article in Nanotechnology, science and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Aerosol Jet Printing in Biotechnologies.Bioengineering (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In tissue engineering, there is a growing need for patient-specific strategies that enable precise control of cellular behaviour - such as adhesion, proliferation, and migration - to enhance tissue integration and reduce transplant rejection. Engineering the physicochemical properties and topography of substrates is a promising way to guide cell responses. Among available materials, graphene nanoplatelets offer outstanding physicochemical, electrical, and mechanical properties, making them ideal for biomedical use. Moreover, printed electronics techniques allow efficient, cost-effective fabrication of continuous coatings or intricate micropatterns on flexible substrates. Methods: Graphene nanoplatelet patterns were fabricated on flexible thermoplastic polyurethane substrates using inkjet and aerosol jet printing to compare the methods and their influence on cell behaviour. Layers were analysed for morphology, topography, and electrical properties (SEM, Raman spectroscopy, profilometry, electrical measurements). Surface wettability and surface free energy were measured via contact angle measurements. L929 fibroblast cells were cultured on printed patterns and assessed by confocal microscopy and MTT assay. Results and Discussion: Graphene patterns significantly improved cell proliferation compared to TPU controls. Cells aligned and migrated along printed graphene features, especially on aerosol jet-printed patterns, which promoted attachment and spreading. Quantitative analysis confirmed enhanced cell coverage and proliferation, highlighting the potential of graphene micropatterns for precise cellular control in regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.