ArticleJournal of traditional and complementary medicine2025
Polysaccharides derived from alkali-extracted vinegar-baked
Article in Journal of traditional and complementary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: New immunosuppressants with good efficacy and high safety are urgently needed to address immune rejection following organ transplantation. The study aimed to investigate the effect of alkali-extracted vinegar-baked Methods: KVBCP was separated by membrane separation technology, and the physicochemical properties were analyzed by chemical and instrument method. The hyperimmune T lymphocyte model was used to screen the immunosuppressive activity of KVBCP fractions by examining the effects on lymphocyte proliferation and CD4 Results: Five KVBCP fractions (KVBCP1, KVBCP2, KVBCP3, KVBCP4 and KVBCP5) were obtained. They all showed characteristic absorption peaks of polysaccharides in the FT-IR spectra, but their molecular weights and monosaccharide compositions were different. Five KVBCPs all inhibited the proliferation of T lymphocytes and suppressed the proportion of CD4 Conclusion: KVBCPs, especially KVBCP3 and KVBCP4, suppress hyperimmune T lymphocytes and ameliorate skin graft rejection through correcting the imbalance of Th1/Th2 and Th17/Tregs.
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