Evidence map›Paper›PMID 41262669›Full record

ArticleJournal of traditional and complementary medicine2025

Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention.

Wen-Yu Hsieh, Chu-Nien Yu, Chang-Chang Chen, Chun-Tang Chiou, Brian D Green, Oscar K Lee, Chia-Chune Wu, Ly Hien Doan, Chi-Ying F Huang, Cheng Huang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Green Synthesis and Quality-by-Design Optimization ofMolecules (Basel, Switzerland) · 2026
    Article
  3. Integrated Evaluation ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wen-Yu HsiehBiomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Chu-Nien YuInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Chang-Chang ChenDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 11221, Taiwan.
Chun-Tang ChiouDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 11221, Taiwan.
Brian D GreenInstitute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, BT7 1NN, UK.
Oscar K LeeBiomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Chia-Chune WuBiomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Ly Hien DoanInstitute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Chi-Ying F HuangInstitute of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Cheng HuangDepartment of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang Ming Chiao Tung, Taipei, 11221, Taiwan.
Chien-Ju LiuTea and Beverage Research Station, Ministry of Agriculture, Yangmei Township, Taoyuan County, 326011, Taiwan.
Yu-Hsin ChenTaichung District Agricultural Research and Extension Station, Ministry of Agriculture, Chang-Hwa County, 515008, Taiwan.
Jing-Jy ChengDivision of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 11221, Taiwan.
Heng-Chih PanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung City, 204201, Taiwan.
Hui-Kang LiuDivision of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, 11221, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus infect the respiratory tract through surface proteins, causing similar symptoms. Since the onset of the COVID-19 pandemic, both viruses have posed significant ongoing global health threats. Like the influenza virus, SARS-CoV-2 evolves into variants that can reduce vaccine efficacy. Thus, herbal medicines are being explored as supplementary options to enhance protection against these infections. This study aimed to investigate the therapeutic potential of chlorogenic acid (3-CQA) and related extracts from green coffee beans and

Indexed as

Chlorogenic acidCOVID-19Echinacea purpureaGreen coffee beanH1N1 influenza virusSARS-CoV-2 variantsSpike protein

Identifiers

PMID41262669
PMCPMC12624562

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.