Evidence map›Paper›PMID 41262564›Full record

ArticleACS pharmacology & translational science2025

Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain.

Sara Hestehave, Silvia Dragoni, Philip Fallon, Filipa Mota, Aida Calderon-Rivera, Kimberly Gomez, Jonathan Powell, Anastasia Patsiarika, Tifelle Reisinger, Stuart Crosby and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sara HestehaveDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, New York 10010, United States.ORCID https://orcid.org/0000-0002-1837-521X
Silvia DragoniUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1 V 9EL, U.K.
Philip FallonNCE Discovery (Domainex Ltd), Chesterford Research Park, Little Chesterford, Saffron Walden, Essex CB10 1XL, U.K.
Filipa MotaThe Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, U.K.
Aida Calderon-RiveraDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, New York 10010, United States.
Kimberly GomezDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, New York 10010, United States.
Jonathan PowellNCE Discovery (Domainex Ltd), Chesterford Research Park, Little Chesterford, Saffron Walden, Essex CB10 1XL, U.K.
Anastasia PatsiarikaThe Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, U.K.
Tifelle ReisingerNCE Discovery (Domainex Ltd), Chesterford Research Park, Little Chesterford, Saffron Walden, Essex CB10 1XL, U.K.
Stuart CrosbyNCE Discovery (Domainex Ltd), Chesterford Research Park, Little Chesterford, Saffron Walden, Essex CB10 1XL, U.K.
A W Edith ChanThe Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, U.K.ORCID https://orcid.org/0000-0003-2321-6296
David SteadmanThe Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, U.K.
Natalie WinfieldNCE Discovery (Domainex Ltd), Chesterford Research Park, Little Chesterford, Saffron Walden, Essex CB10 1XL, U.K.
Ashley JarvisNCE Discovery (Domainex Ltd), Chesterford Research Park, Little Chesterford, Saffron Walden, Essex CB10 1XL, U.K.
John MartinCentre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street ,London WC1E 6JJ, U.K.
Ian C ZacharyCentre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street ,London WC1E 6JJ, U.K.
Paul FrankelInstitute of Cardiovascular Science, University College London, 5 University Street, London WC1E 6JF, U.K.
Snezana DjordjevicInstitute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Christiana RuhrbergUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1 V 9EL, U.K.
Rajesh KhannaDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, New York 10010, United States.ORCID https://orcid.org/0000-0002-9066-2969
David L SelwoodThe Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, U.K.ORCID https://orcid.org/0000-0002-6817-5064

Funding

Validation of Neuropilin-1 Receptor Signaling in Nociceptive ProcessingRF1NS131165 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2023 to 2023
$2.0M
Validation of Neuropilin-1 Receptor Signaling in Nociceptive ProcessingR01NS131165 · NINDS · UNIVERSITY OF FLORIDA · PI Rajesh Khanna · 2026 to 2026
$694k
NINDS NIH HHS R01 NS131165NINDS NIH HHS RF1 NS131165
6 · The paper itself

Abstract

Nociceptive pain, resulting from tissue injury or inflammation, affects a large portion of the global population. This type of pain is commonly treated by small molecules that are associated with a variety of drawbacks, including addiction and potential liver or kidney damage, highlighting the need for new therapeutic strategies. Here, we report the design, synthesis, and characterization of EG01449 (

Indexed as

antinociceptivechronic painneuropilinNRP1VEGF

Identifiers

PMID41262564
PMCPMC12624434

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.