ArticleACS pharmacology & translational science2025
Comparative Analysis of Species-Specific Hepatocyte Function and Drug Effects in a Liver Microphysiological System PhysioMimix LC12 and 96-Well Plates.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- A targeted lipidomics workflow for high-throughput phenotyping and mechanism-based in vitro hepatotoxicity studies.Toxicology in vitro : an international journal published in association with BIBRA · 2026Article
- Assessing drug-induced liver injury liabilities in human and animal hepatocytes under static and perfused spheroid culture conditions.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- New Frontiers of Drug Development Through the Use of New Approach Methodologies.The AAPS journal · 2026Review
- Hepatocyte Models for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comparative Analysis of Non-HepG2 Cell Models.International journal of molecular sciences · 2026Review
- Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects.Archives of toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Drug-induced liver injury (DILI) remains a challenge in drug development, and interspecies differences in liver toxicity represent a need where comparative analyses may inform preclinical safety study design. In vitro testing for species-specific liver effects, especially in complex models such as microphysiological systems (MPS), may help predict toxicity before advancing from animal to human studies, or derisk spurious findings in preclinical species. This study assessed the utility of the perfusion-based PhysioMimix LC12 MPS as compared to 2D cultures and evaluated species-specific DILI using primary hepatocytes from human, monkey, rat, and dog. Functional, phenotypic, and transcriptional profiles were evaluated for up to 14 days. Also, cells were exposed to species-specific hepatotoxicants such as bosentan (BOS), fialuridine (FIAU), and a common hepatotoxicant for all species, chlorpromazine (CPZ)in both PhysioMimix LC12 and traditional 2D cultures. Hepatocytes in PhysioMimix LC12 showed more stable albumin and urea production as compared to 2D cultures. Concentration-response studies with CPZ, BOS, and FIAU were performed in 2D; then, repeated (5 × every 2 days) exposures to sub-100 ×
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.