Global Burden of Inflammatory Bowel Disease Among Women of Reproductive Age From 1990 to 2021 and Future Projections to 2050: A Comprehensive Analysis Using Eight Machine Learning Algorithms.

Background: To comprehensively analyze the global burden of inflammatory bowel disease (IBD) among women of reproductive age from 1990 to 2021 and make future projections to 2050. Methods: We utilized GBD2021 data to conduct a comprehensive analysis of IBD burden across five social-demographic index (SDI) regions, 21 GBD regions, and 204 countries. We assessed trends in IBD-related incidence, prevalence, mortality, and disability-adjusted life years (DALYs) and performed decomposition analysis to identify contributing factors. Additionally, we predicted the future trends of IBD burden from 2022 to 2050 using eight machine learning models. Results: From 1990 to 2021, global IBD burden among women of reproductive age showed a slight upward trend in incidence, prevalence, DALYs, and mortality. Population growth was the primary contributor to these increases. Significant regional disparities were observed, with high SDI regions continuing to bear the heaviest burden. While mortality rates declined in high SDI regions due to improved healthcare, low- and lower-middle SDI regions experienced higher mortality due to limited resources and access to diagnostic and treatment options. Age-specific trends revealed a higher burden in older age groups (40-49), while younger women (20-24) in low SDI regions exhibited higher mortality and disability. Conclusion: This study provides in-depth insights into the global burden of IBD among women of reproductive age, which can guide the formulation of targeted prevention and management strategies and rational resource allocation to address the challenges posed by IBD in the future.