ArticlePolish journal of radiology2025
Correlation between metabolite concentrations in the frontal lobes, determined using
Article in Polish journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Foetal alcohol spectrum disorder (FASD) is a broad term describing a range of conditions that may be caused by prenatal exposure to alcohol. The aim of this study is to assess the relationship between the metabolism in the frontal lobes of the brain and the IQ in children with FASD. Material and methods: The study assessed a total of 124 children of both genders, aged 5-17 years, with diagnosed FASD, including 62 children with foetal alcohol syndrome (FAS), 34 children with partial foetal alcohol syndrome (pFAS), and 28 children with alcohol-related neurodevelopmental disorder (ARND). The Wechsler Intelligence Scale for Children (WISC-R) and proton magnetic resonance spectroscopy ( Results: There was a statistically significant difference in IQ scores between the group of children with FASD (mean 90.42) and the control group (mean 121.26). In Conclusions: Children with FASD have a significantly lower IQ than their peers from a healthy control group. This may be linked to the changes in the frontal lobes caused by prenatal alcohol consumption, in particular the elevated lipid levels.
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