Evidence map›Paper›PMID 41262443›Full record

ArticleFrontiers in medicine2025

Concurrent anti-glomerular basement membrane disease and membranous nephropathy: a case report.

Lin-Lin Li, Pei-Yuan Niu, Na Li, Xiao-Ling Zhang, Hui-Xia Cao

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lin-Lin LiRenal Division, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Pei-Yuan NiuRenal Division, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Na LiRenal Division, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Xiao-Ling ZhangRenal Division, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Hui-Xia CaoRenal Division, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-glomerular basement membrane (GBM) disease is a rapidly progressive glomerulonephritis which, in rare instances, occurs concurrently with membranous nephropathy (MN). We report a case of this patient presented with proteinuria and hematuria, the predominant pathology was crescentic and necrotizing glomerulonephritis with linear staining for immunoglobulin G (IgG) along the glomerular basement membrane (GBM) associated with epi-membranous electron dense immune deposits. The patient tested had significant titers of anti-GBM antibodies (196.27 RU/ml; reference range:0-20 RU/ml), and renal biopsy demonstrated diffuse strongly positive granular staining for phospholipase a2 receptor (PLA2R) along the GBM. The patient received therapy including prednisone, plasmapheresis and CD20 antibodies, which resulted in the clearance of anti-GBM antibodies and eventual recovery of renal function, as evidenced by the return of serum creatinine to normal levels. Earlier diagnosis and timely effective treatments could improve patients' prognosis.

Indexed as

anti-glomerular basement membrane (GBM) diseasediagnosismembranous nephropathy (MN)phospholipase A2 receptor (PLA2R)prognosistreatment

Identifiers

PMID41262443
PMCPMC12623194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.