Evidence map›Paper›PMID 41262350›Full record

ArticleChemical science2026

A printable, unimolecular, core-shell polymer bottlebrush-based signal transducer using solvatochromatic reporting.

Chenyou Zhang, Samantha O Catt, Tom Hawtrey, Ping Zeng, Haoxiang Zeng, Simran D Kerai, Yen Theng Cheng, Moritz P Hopp, Qinqin Yang, Elizabeth J New and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenyou ZhangKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.
Samantha O CattInstitute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University 69120 Heidelberg Germany eva.blasco@uni-heidelberg.de.ORCID https://orcid.org/0000-0001-8245-4150
Tom HawtreySchool of Chemistry, The University of Sydney Sydney NSW 2006 Australia.
Ping ZengKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.
Haoxiang ZengKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.ORCID https://orcid.org/0000-0001-8554-4717
Simran D KeraiKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.ORCID https://orcid.org/0009-0007-9153-8621
Yen Theng ChengKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.
Moritz P HoppInstitute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University 69120 Heidelberg Germany eva.blasco@uni-heidelberg.de.
Qinqin YangKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.
Elizabeth J NewSchool of Chemistry, The University of Sydney Sydney NSW 2006 Australia.ORCID https://orcid.org/0000-0002-2310-254X
Eva BlascoInstitute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University 69120 Heidelberg Germany eva.blasco@uni-heidelberg.de.ORCID https://orcid.org/0000-0002-0849-4223
Markus MüllnerKey Centre for Polymers & Colloids, School of Chemistry, The University of Sydney Sydney NSW 2006 Australia markus.muellner@sydney.edu.au.ORCID https://orcid.org/0000-0002-0298-554X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of stimuli-responsiveness, colloidal stability and tolerance to changes in concentration and ionic strength into a functional nanoparticle system is challenging. Self-assembled polymer materials remain susceptible to environmental changes, which in turn limit their application potential. Unimolecular architectures like bottlebrush polymers offer enhanced stability and functional compartmentalisation within a single macromolecule. Here, we report the synthesis of a pH-responsive molecular polymer bottlebrush (MPB) featuring a poly[(diisopropylamino)ethyl methacrylate] (PDPAEMA) core, a hydrophilic poly[poly(ethylene glycol) methyl ether methacrylate] (PPEGMA) shell, and naphthalimide-based solvatochromic fluorophores embedded within its core. The PDPAEMA segment imparts pH sensitivity, while the PEGMA shell improves colloidal stability and biocompatibility. The solvatochromic dyes report environmental changes by responding to polarity shifts in the polymer architecture and polymer networks. Our proof-of-concept study promises future application of such unimolecular constructs as nanoscale pH sensors for biomedicine or as functional additives for 3D printing capable of reporting environmental changes within a printed network or (hydro)gel.

Identifiers

PMID41262350
PMCPMC12624358

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.