Evidence map›Paper›PMID 41262344›Full record

ArticleChemical science2026

Electricity-driven site-selective deuteration of pharmaceuticals.

Minling Zhong, Feihu Wang, Guanqun Han, Shuai Yuan, Guodong Li, De-En Jiang, Yujie Sun

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minling ZhongDepartment of Chemistry, University of Cincinnati Cincinnati OH 45221 USA yujie.sun@uc.edu.
Feihu WangDepartment of Chemistry, University of Cincinnati Cincinnati OH 45221 USA yujie.sun@uc.edu.
Guanqun HanDepartment of Chemistry, University of Cincinnati Cincinnati OH 45221 USA yujie.sun@uc.edu.
Shuai YuanDepartment of Chemical & Biomolecular Engineering, Vanderbilt University Nashville TN 37235 USA de-en.jiang@vanderbilt.
Guodong LiDepartment of Chemistry, University of Cincinnati Cincinnati OH 45221 USA yujie.sun@uc.edu.
De-En JiangDepartment of Chemical & Biomolecular Engineering, Vanderbilt University Nashville TN 37235 USA de-en.jiang@vanderbilt.ORCID https://orcid.org/0000-0001-5167-0731
Yujie SunDepartment of Chemistry, University of Cincinnati Cincinnati OH 45221 USA yujie.sun@uc.edu.ORCID https://orcid.org/0000-0002-4122-6255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision deuteration at metabolically vulnerable sites of pharmaceuticals can enhance drug stability and therapeutic efficacy, yet existing methods often suffer from poor selectivity and inefficiency. Here, we report an electricity-driven bromine-mediated deuteration strategy that enables late-stage site-selective deuteration of pharmaceuticals using D

Identifiers

PMID41262344
PMCPMC12626438

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.