ArticleReproductive medicine and biology
The Trigger Effect of GnRH Agonist Repeated Dose on Intracytoplasmic Sperm Injection Outcomes: A Randomized Single-Blinded Clinical Trial.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Empty Follicle Syndrome: Current Therapeutic Approaches and the Role of Triggering Agents in Assisted Reproductive Technology.Medical sciences (Basel, Switzerland) · 2026Review
- The Trigger Effect of GnRH Agonist Repeated Dose on Intracytoplasmic Sperm Injection Outcomes: A Randomized Single-Blinded Clinical Trial.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The optimal GnRH agonist (GnRHa) dosing for ovulation triggering remains controversial, particularly regarding oocyte competence versus OHSS mitigation. Here, we analyzed the repeated dose of GnRHa as a trigger of ovulation on intracytoplasmic sperm injection (ICSI) results. Methods: This single-blinded randomized clinical trial was conducted on 362 ICSI candidates who met the inclusion criteria. The subjects underwent the antagonist protocol and based on the received trigger, were divided into two groups: single dose (group A) and repeated dose (group B) of GnRHa. Demographic and clinical data were collected and analyzed using SPSS-24. Results: Repeated dosing of GnRH increased M2 oocyte numbers yield by 22.84% ± 6.92% (95% CI: 9.23-25.38, Conclusion: It seems that the administration of the second dose of GnRHa 12 h after the first dose leads to better oocyte maturation and higher quality embryos. Trail Registration: IRCT20081007001306N11; https://irct.behdasht.gov.ir/trial/60387.
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