Trial reportWorld journal of clinical pediatrics2025
Efficacy and palatability of the developed polyethylene glycol-based formula for the treatment of children with functional constipation.
Trial report in World journal of clinical pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Clinical Efficacy and Safety of Shenqu Xiaoshi Oral Liquid for Functional Constipation in Children: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcipients may improve the palatability of polyethylene glycol (PEG), the first-line treatment for childhood functional constipation (FC), leading to good compliance and improved treatment outcomes.
aimTo compare the developed PEG-based formula (PEG-Chula) to the commercial formula for treating childhood FC.
methodsIn this randomized controlled trial, we enrolled children aged < 18 years with FC diagnosed by the Rome IV criteria to receive PEG-Chula [four flavors: (1) Strawberry; (2) Lychee; (3) Apple; and (4) Lychee-rose] or Forlax (orange-grapefruit flavor) for eight weeks. The primary outcomes included changes in stool frequency and consistency measured by the Bristol Stool scale. The secondary outcomes were constipation-related symptom improvement, adverse events, and palatability measured by the facial hedonic scale.
resultsFifty-two children diagnosed with FC [median age: 4.21 (2.33, 7.88) years; 35 (67.31%) females] were enrolled. After the 8-week treatment, the mean weekly stool frequency increased in both groups, the mean change was 4.02 (95%CI: 3.09-4.95) in PEG-Chula and 3.78 (95%CI: 2.79-4.78) in commercial PEG compared to baseline (
conclusionBoth PEG-based formulas are effective and safe for managing pediatric FC.
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