Trial reportIranian journal of medical sciences2025
Heart Rate Variability and Blood Pressure Response to Low-Intensity Endurance Exercise Training Plus Blood Flow Restriction in Individuals with Mild Hypertension: A Randomized Controlled Clinical Trial.
Trial report in Iranian journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of blood flow restriction training on cardiovascular autonomic function in middle-aged and older adults: a meta-analysis.Scientific reports · 2026Pooled it
- Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia?Physiological reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Given limited available data and information gaps related to the effects of endurance exercise along with blood flow restriction (BFR) on the heart. This study examined the effects of low-intensity endurance exercise training (Ex) alone and BFR on blood pressure (BP), electrocardiogram (ECG), heart rate variability (HRV), and heart rate recovery time (HRRT) in participants with grade 1 hypertension. Methods: In this randomized double-blind clinical trial, 43 hypertensive participants, 50-65 years old, were randomly divided into three groups: Ex+BFR, Ex, and the control (Con) group. The training program was conducted three times weekly for 10 weeks in spring 2024 at Kerman University of Medical Sciences. Before and 24 hours after the intervention, HRV parameters, BP, ECG, and HRRT were assessed. Results: The Ex and Ex+BFR groups showed a significant increase in Root Mean Square of Successive Differences between normal heartbeats (RMSSD) (P=0.008, P=0.002), Standard Deviation of Successive Differences (SDSD) (P=0.008, P=0.002), and the standard deviation of the Poincaré plot ratio (SD1/SD2) (P=0.0004, P=0.0002), and a reduced low frequency to high frequency ratio (LF/HF) (P=0.013 and P=0.007) compared to Con group, respectively. The Ex+BFR group demonstrated a greater positive effect on frequency-domain parameters of HRV. In addition, both the Ex and Ex+BFR groups showed a significant reduction in HRRT (P=0.0001 vs. relevant baseline), mean arterial blood pressure (MAP) (P=0.0001), and prolonged PR interval (P=0.038 and P=0.035, respectively) and shortened QRS complex compared to the Con group. Conclusion: This study demonstrates that combining low-intensity endurance exercise with BFR exerts a positive effect on cardiovascular parameters such as BP, ECG, HRRT, and demonstrates superior effects on HRV compared to exercise alone in individuals with mild hypertension. A preprint version of this manuscript is available at DOI: https://doi.org/10.21203/rs.3.rs-5347658/v1.
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